2016 Fiscal Year Final Research Report
Cellular response to the novel carbonate apatite bone substitute activating bone regeneration
| Project/Area Number |
26462984
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Dental engineering/Regenerative dentistry
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| Research Institution | Asahi University |
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Principal Investigator |
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| Research Collaborator |
Kondo Yuzo
Takahashi Jun
Onoe Ippei
Osaki Kosuke
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| Project Period (FY) |
2014-04-01 – 2017-03-31
|
| Keywords | 炭酸含有アパタイト / バイオセラミックス / 骨補填材 / 生体親和性 / 骨再生 / MAPK / インテグリン / 破骨細胞 |
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| Outline of Final Research Achievements |
In order to develop a novel bone substitute material that functions as a adequate scaffold of recipient’s cells and activates bone regeneration after transplantation, carbonate-containing apatite (CA) bone substitute material of three kinds of sintering conditions was prepared. To estimate the effects of CA on the cellular activities, several experiments in culture and transplantation experiments on animal models were carried out. As a result, sintered CA at 700 ° C, promoted cell adhesion, cell proliferation, osteoblastic and osteoclastic differentiation. The CA also showed solubility by osteoclasts. These results suggested that our CA was a material with good potential for activating bone regeneration.
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| Free Research Field |
口腔生化学 細胞生物学 生体材料学
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