Modulatory effect of fluvastatin upon immune suppression regulated by mesenchymal stromal cells and oral squamous cell carcinoma cells

2016 Fiscal Year Final Research Report

• Project/Area Number: 26463055
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Surgical dentistry
• Research Institution: Asahi University
• Principal Investigator: Kondoh Nobuo 朝日大学, 歯学部, 教授 (40202072)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 口腔扁平上皮癌 / 間葉系間質細胞 / 免疫抑制 / fluvastatin

Outline of Final Research Achievements

We have established sub-clones from primary and metastasized oral squamous cell carcinoma (OSCC) from primary and metastasized tumors of tumor-implanted mice. IFN-gamma-producing capability of antigen-stimulated spleen cells from all of the tumor-implanted mice was significantly lower than that of control mice. IL-10-producing capability of spleen cells from tumor-bearing mice implanted with metastasized sub-clones was reduced, while that of the spleen cells from the mice implanted with non-metastasized sub-clones was increased. Polymorpho nuclear (PMN)- myeloid derived suppresser cells (MDSCs) were significantly increased in mice implanted with metastasized sub-clones. Our results demonstrate that OSCCs exert differential effects on the immune regulatory mechanisms, depending on their malignancy, i.e., metastatic potential.

Free Research Field

医歯薬学