Genome epidemiological study on sleep and mental health

2017 Fiscal Year Final Research Report

• Project/Area Number: 26507006
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: 睡眠科学
• Research Institution: Shiga University of Medical Science
• Principal Investigator: Kadotani Hiroshi 滋賀医科大学, 医学部, 特任教授 (90362516)
• Co-Investigator(Renkei-kenkyūsha): Yoshikawa Takeo 理化学研究所, 脳科学総合研究センター, チームリーダー (30249958) ; Owada Yuji 東北大学, 大学院 医学系研究科, 教授 (20292211)
• Research Collaborator: Gerstner Jason R. Washington State University ; Perron Isaac J. University of Pennsylvania ; Riedy Samantha M. Washington State University ; Van Dongen Hans P. A. Washington State University ; Galante Raymond J. University of Pennsylvania ; Dickinson Kaitlin University of Wisconsin-Madison ; Yin Jerry C. P. University of Wisconsin-Madison ; Pack Allan I. University of Pennsylvania ; Frank Marcos G. Washington State University
• Project Period (FY): 2014-04-01 – 2018-03-31
• Keywords: 睡眠障害 / メンタルヘルス / ゲノム / 疫学

Outline of Final Research Achievements

The mammalian brain-type fatty acid binding protein (Fabp7) is expressed in astrocytes. We found from our genome epidemiological study that the missense mutation FABP7.T61M is associated with fragmented sleep. This phenotype was recapitulated in mice and fruit-flies bearing similar mutations. This was a result from an international collaborating study.

Free Research Field

睡眠