Novel signaling pathway of bacterial stress responses and host defense via autophagy

2015 Fiscal Year Final Research Report

• Project/Area Number: 26670207
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Bacteriology (including mycology)
• Research Institution: Tohoku University
• Principal Investigator: AKAIKE Takaaki 東北大学, 医学系研究科, 教授 (20231798)
• Co-Investigator(Kenkyū-buntansha): MATSUNAGA Tetsuro 東北大学, 大学院医学系研究科, 助教 (00723206) ; IDA Tomoaki 東北大学, 大学院医学系研究科, 助教 (70570406)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: 細菌 / シグナル伝達 / オートファジー / 活性酸素 / レドックス

Outline of Final Research Achievements

To clarify the molecular mechanism of pathogenesis of bacterial infection, we investigated the functions of 8-nitro-cGMP which is a signaling molecule both in bacteria and host cells. Protein S-guanylation induced by 8-nitro-cGMP was involved in stress responses in bacteria, and also play an important role in antibacterial host defense via autophagy. Hydrogen sulfide and reactive sulfur species produced by bacteria were suggested to regulate signaling function of 8-nitro-cGMP and to be involved in bacterial growth in infected cells.

Free Research Field

細菌学