Development of a PET organic imaging probe to visualize metal related reaction in vivo

2016 Fiscal Year Final Research Report

• Project/Area Number: 26670553
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Radiation science
• Research Institution: Hamamatsu University School of Medicine
• Principal Investigator: Magata Yasuhiro 浜松医科大学, 光尖端医学教育研究センター, 教授 (20209399)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: PET / がん / C-11 / 金属錯体 / マウス

Outline of Final Research Achievements

There are many metal related biochemical reactions in the living cells. To image these reactions in vivo without radio-metal nuclide is expected to be useful for pathological elucidation of trace metal related diseases. In this study, we aim to develop a novel PET organic imaging probe for these reactions. Cu-ATSM was selected for a model compound of our POC. C-11-Cu-ATSM-D1 was obtained by C-11 methylation of Cu-ATSM-D2 by optimization of several reaction parameters. Accumulation of radioactivity post injection of C-11-ATSM-D1 in the tumor was observed in vivo and the distribution of the radioactivity in the tumor was heterogeneous. POC can be obtained with more studies.

Free Research Field

病態機能分析学・核薬学