Regeneration study of maxillofacial nerve using of artificial nerve tube with self mononuclear leukocyte (BMC) derived from bone marrow.

2015 Fiscal Year Final Research Report

• Project/Area Number: 26670864
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Surgical dentistry
• Research Institution: Kyoto University
• Principal Investigator: Shigeno Keiji 京都大学, 再生医科学研究所, その他 (00162587)
• Co-Investigator(Kenkyū-buntansha): NAKAMURA TATSUO 京都大学, 再生医科学研究所, 准教授 (70227908)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: 人工神経管 / PGA-コラーゲンチューブ / 骨髄由来単核球(BMC) / 再生痛 / 神経再生実験 / 神経再生の質

Outline of Final Research Achievements

We were able to confirm that the trigeminal nerve which controlled difficulty and the maxillofacial which had been done, the exercise of maxillofacial and perception corresponded, and regeneration could provide improvement of speed of the nerve regeneration and the quality until now by gathering mononuclear leukocyte (BMC) derived from dog marrow than a host in this study, and using it for nerve damage region with an artificial neural tube (P.G.A. collagen tube) which We developed in a laboratory. In addition, We were able to confirm that We restrained "a pain - regeneration pain” to develop in the case of neurologic regeneration healing by this experiment as much as possible and bring about prompt nerve regeneration.

Free Research Field

医歯薬学