Development of detection systems for polyphenols that inhibit osteoclast formation and its applications

2015 Fiscal Year Final Research Report

• Project/Area Number: 26670906
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Social dentistry
• Research Institution: Nagasaki University
• Principal Investigator: TSUKUBA Takayuki 長崎大学, 医歯薬学総合研究科(歯学系), 教授 (30264055)
• Co-Investigator(Kenkyū-buntansha): OKAMOTO Kuniaki 長崎大学, 医歯薬学総合研究科(歯学系), 准教授 (10311846) ; SAKAI Eiko 長崎大学, 医歯薬学総合研究科(歯学系), 助教 (10176612)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: 破骨細胞 / ポリフェノール

Outline of Final Research Achievements

Control of decreased expression levels of hemeoxygenase-1 (HO-1) is essential for the development of osteoclast formation. Addition of oxidants inducing HO-1 is thought to inhibit the osteoclast formation. One of the candidates is polyphenols in foods. However, numerous polyphenols remain to be identified. In this study, we constructed rapid and simple systems for detecting polyphenols that inhibit osteoclast formation. By the methods, we will analyze the identified polyphenols. Consequently, the drugs or supplements that prevent bone absorption by osteoclasts will be developed in future.

Free Research Field

歯科薬理学