2018 Fiscal Year Final Research Report
Manipulation of blood lactate concentration against obesity
| Project/Area Number |
26702029
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Partial Multi-year Fund |
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| Research Field |
Sports science
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| Research Institution | Ritsumeikan University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2019-03-31
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| Keywords | 代謝疾患 / 運動 / サプリメント / 加齢 / 筋肥大 / サルコペニア / 糖代謝 / 肥満 |
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| Outline of Final Research Achievements |
I have been focusing on the lactate metabolism, and found that it functions as an inducer of cell signaling in skeletal muscle cells (e.g., increased mitochondrial biogenesis and myogenesis) and adipocytes (e.g., increased lipases expression). The aim of this study was to examine whether manipulation of blood lactate concentration can be a therapeutic strategy against obesity and metabolic disorder by reducing fat mass and preventing muscle atrophy. I found that the supplementation of lactate-based compound elicits muscle hypertrophy, reduces fat mass, and improves glucose metabolism. These findings suggest that lactate may be a beneficial molecule against obesity and metabolic disorder.
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| Free Research Field |
運動生理・生化学
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| Academic Significance and Societal Importance of the Research Achievements |
健康増進に対する運動効果は周知の事実であるが、そのメカニズムは多面的である。その中で、運動（特に高強度の運動）誘発性の乳酸が運動効果の分子機序の一つとして機能し得ることを、細胞、動物、ヒトを対象とした多角的な実験的検証から明らかにした。このことは、特に乳酸産生を促すような運動の有用性を示唆するとともに、サプリメントなど、外的に乳酸を付加することの有用性も示唆しており、広く万人に有効な肥満と代謝疾患の予防・改善に繋がる知見を提供し得た。
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