Epigenetic dysregulation of homeobox genes in radiation-induced rat mammary carcinogenesis

2016 Fiscal Year Final Research Report

• Project/Area Number: 26740022
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Risk sciences of radiation and chemicals
• Research Institution: National Institutes for Quantum and Radiological Science and Technology
• Principal Investigator: Daino Kazuhiro 国立研究開発法人量子科学技術研究開発機構, 放射線医学総合研究所 放射線影響研究部, 主任研究員(定常) (90543299)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 放射線 / 乳がん / エピジェネティクス

Outline of Final Research Achievements

The mammary gland is one of the most sensitive organs to radiation carcinogenesis. However, epigenetic dysregulation in radiation-induced breast cancer have yet to be well characterized. In this study, we obtaiined results suggesting the involvement of epigenetic dysregulation of homeobox genes in radiation-induced rat mamamry carcinogenesis. In addition, we identified mutations in several epigenetic regulator genes in radiation-induced rat mammary carcinomas.

Free Research Field

放射線生物学