What is the difference among mechanisms that regulate the nuclear positioning in various cell types?

2015 Fiscal Year Final Research Report

• Project/Area Number: 26840072
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Cell biology
• Research Institution: National Institute of Genetics
• Principal Investigator: kimura kenji 国立遺伝学研究所, 構造遺伝学研究センター, 助教 (40644505)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: 核配置 / 細胞質流動 / キネシン / 線虫

Outline of Final Research Achievements

In this study, I analyzed the dynamics of the nucleus in the fertilized embryo and in the multinucleated intestinal cell of C. elegans to reveal a diverse mechanisms of the nuclear positioning in the cell. Previously, a motor protein dynein has been known as a major regulator of the nuclear positioning. I found that (1) the sperm-derived nucleus utilizes cytoplasmic streaming that emerges after fertilization to position itself in the proper location in the embryo, and (2) a motor protein kinesin-1 is involved in the nuclear positioning in the intestinal cell. This study will reveal new mechanisms of the nuclear positioning in various cell types.

Free Research Field

細胞生物学