2016 Fiscal Year Final Research Report
Study on molecular mechanism of influenza virus infections in chickens
| Project/Area Number |
26850178
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Veterinary medical science
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| Research Institution | Hokkaido University |
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Principal Investigator |
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| Research Collaborator |
NISHIHARA Syoko 創価大学, 工学部, 教授
TAKASE Sayaka 創価大学, 工学部, 教授
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | インフルエンザウイルス / レセプター / ニワトリ / ヘマグルチニン / 膜融合活性 / ノイラミニダーゼ |
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| Outline of Final Research Achievements |
To reveal mechanism of intersperses transmission of avian influenza viruses between ducks, natural host, and chickens. We revealed that chicken influenza viruses preferentially bind to not only fucosylated but also sulfated alpha 2,3 sialoglycans as the receptor. These receptors were actually detected epithelial cells of chicken trachea, where virus replicate. Furthermore, membrane fusion activity of hemagglutinin protein between virus envelop and cell membrane are related to pathogenicity to chickens in some viruses, not all. Difference of neuraminidase activity of virus which derived from deletion of the stalk region also related to the pathogenicity to chickens. Our results indicate that several virus proteins are responsible for virus transmission and pathogenicity of avian influenza viruses to chickens.
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| Free Research Field |
獣医微生物学
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