2015 Fiscal Year Final Research Report
Investigation of the mechanism underlying the effect of fatty acid on colorectal carcinogenesis
| Project/Area Number |
26860517
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Gastroenterology
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| Research Institution | Yokohama City University |
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Principal Investigator |
ENDO HIROKI 横浜市立大学, 附属病院, 助教 (70468164)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
|
| Keywords | 大腸発癌 / 脂肪酸 |
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| Outline of Final Research Achievements |
We established the method how to evaluate the effect of saturated fatty acid on colorectal carcinogenesis by continuous jugular infusion or intraperitoneal injection of fatty acid. We clarified that saturated fatty acid (palmitate) acts as a growth factor for colonic epithelial cell proliferation in colon carcinogenesis via saturated fatty acid/Toll-like receptor 4/JNK pathway.
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| Free Research Field |
医歯薬学
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