2015 Fiscal Year Final Research Report
The mechanism of erythroid lineage caused by Myh9 R702C mutation
| Project/Area Number |
26860725
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Hematology
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| Research Institution | Nagoya University |
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Principal Investigator |
Suzuki Nobuaki 名古屋大学, 医学部附属病院, 助教 (70637686)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Keywords | MYH9 / 赤血球 |
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| Outline of Final Research Achievements |
We generated hematopoietic stem cell(HSC)-specific Myh9 R702C mice, and estimated red blood cells (RBCs) and cells of the erythroid lineage. HSC-specific Myh9 R702C mice displayed mild anemia and high erythropoietin level compared with wild type mice. However, we could not find no difference in the character of RBC and differentiation of erythroid lineage compared with wild type mice in this research.
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| Free Research Field |
血液学
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