2015 Fiscal Year Final Research Report
New strategy based on anti-oxidant action in eosinophilic chronic rhinosinusitis with nasal polyps
| Project/Area Number |
26861417
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Juntendo University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2016-03-31
|
| Keywords | 好酸球副鼻腔炎 / 鼻茸 / 抗活性酸素因子 / Superoxide dismutase / 好酸球 / マクロファージ / リモデリング |
|---|
| Outline of Final Research Achievements |
Twenty-six patients with CRS with nasal polyps were divided into eosinophilic and non-eosinophilic groups. The expression of three isoforms of SOD, intracellular copper-zinc SOD (CuZnSOD), mitochondrial manganese SOD (MnSOD) and extracellular SOD (ECSOD), were examined by enzyme activity assay, immunohistochemistry, and quantitative real-time RT-PCR sampled by laser capture microdissection.
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| Free Research Field |
耳鼻咽喉科学
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