Elucidation of the role of the depression of nucleocytoplasmic transport relative factor for neuropsychiatric disorder

2016 Fiscal Year Final Research Report

• Project/Area Number: 26870341
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Cell biology; Neurochemistry/Neuropharmacology
• Research Institution: University of Fukui (2016); National Institutes of Biomedical Innovation, Health and Nutrition (2014-2015)
• Principal Investigator: Moriyama Tetsuji 福井大学, 学術研究院医学系部門, 助教 (50627990)
• Research Collaborator: TSUJII Akira 国立研究開発法人医薬基盤・健康・栄養研究所, 細胞核輸送ダイナミクスプロジェクト ; KIMOTO Chihiro 国立研究開発法人医薬基盤・健康・栄養研究所, 細胞核輸送ダイナミクスプロジェクト ; HIKIDA Takatoshi 国立大学法人 京都大学, 大学院医学研究科 ; MORITA Makiko 国立大学法人 京都大学, 大学院医学研究科
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 神経科学 / 核-細胞質間輸送 / 精神疾患

Outline of Final Research Achievements

As humans get older, their memory and concentration will decline. However, the mechanism of memory disturbance due to aging is hardly understood. In this study, we focused on some nuclear-cytoplasmic transport factors reported as candidate factors for neuropsychiatric disorders. As the result, it was found that importin α1 (KPNA1) gene deficient mice had stress vulnerability exhibiting behavioral abnormalities due to stress load. Furthermore, it became clear that importin α is involved in the transport of new biofunctional factors.

Free Research Field

分子生物学、細胞生物学、神経科学