2015 Fiscal Year Final Research Report
Hemokinin-1 mediates pruriceptive processing in the rat spinal cord
| Project/Area Number |
26870451
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General internal medicine(including psychosomatic medicine)
Pain science
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| Research Institution | University of Miyazaki |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Keywords | Hemokinin-1 / itch / scratching |
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| Outline of Final Research Achievements |
The present study demonstrated that the intrathecal administration of [Leu11]-HK-1 attenuated HK-1-induced scratching and the induction of scratching behavior by 5-HT or histamine, indicating that HK-1 is a neurotransmitter or neuromodulator in pruritic processing at the level of the spinal cord. And D-tryptophan (D-Trp) prolongs the duration of effective time of [Leu11]-HK-1.Therefore, it is possible that [Leu11]-HK-1 is a valuable tool for clarifying the underlying mechanism of pruritic processing,but not nociceptive processing at the spinal level.
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| Free Research Field |
精神腫瘍学
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