| Budget Amount *help |
¥110,890,000 (Direct Cost: ¥85,300,000、Indirect Cost: ¥25,590,000)
Fiscal Year 2014: ¥19,370,000 (Direct Cost: ¥14,900,000、Indirect Cost: ¥4,470,000)
Fiscal Year 2013: ¥20,280,000 (Direct Cost: ¥15,600,000、Indirect Cost: ¥4,680,000)
Fiscal Year 2012: ¥21,320,000 (Direct Cost: ¥16,400,000、Indirect Cost: ¥4,920,000)
Fiscal Year 2011: ¥21,060,000 (Direct Cost: ¥16,200,000、Indirect Cost: ¥4,860,000)
Fiscal Year 2010: ¥28,860,000 (Direct Cost: ¥22,200,000、Indirect Cost: ¥6,660,000)
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| Outline of Final Research Achievements |
The eukaryotic genome is tightly packed into the chromatin, a hierarchically organized complex of DNA, histone and nonhistone proteins. Recent findings indicates that histone variant eviction/exchange has an important role in DNA repair and DNA damage response. We found that the TIP60 complex facilitates histone H2AX exchange at the sites of DNA damage. Interestingly, the phosphorylation of histone H2AX is not required for histone H2AX exchange. In this project, we investigated the physiological significance of histone H2AX exchange in DNA damage response. We found that the histone signaling network regulated by the acetylation-dependent histone H2AX exchange is cross-talked with the phosphorylation-dependent DNA damage response signaling.
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