Abnormal Ca and Na pump of cultured vascular smooth muscle cells from hypostensive rats.
Project/Area Number |
02670410
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Research Category |
Grant-in-Aid for General Scientific Research (C)
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Allocation Type | Single-year Grants |
Research Field |
Circulatory organs internal medicine
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Research Institution | Jikei University School of Medicine |
Principal Investigator |
KURIYAMA Satoru Jikei University School of Medicine, Lecturer, 医学部, 講師 (60153384)
|
Project Period (FY) |
1990 – 1991
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Project Status |
Completed (Fiscal Year 1991)
|
Budget Amount *help |
¥2,000,000 (Direct Cost: ¥2,000,000)
Fiscal Year 1991: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1990: ¥1,300,000 (Direct Cost: ¥1,300,000)
|
Keywords | Ca pump / Na pump / SHR / Hypertension / Vascular smooth muscle cells / culture / vascular smooth musde cells / 血管平滑筋細胞膜 / NaーK pump / Caーpump / NaーK contransport / NaーH antiport / 増殖 |
Research Abstract |
To elineate abnormalities in membrane permeability to cations as well as differential characteristic of humoral factors in the etiology of hypertension, Ca and Na transpport kinetics of vascular smooth muscle cells and the effect of serum from spontaneously hypertensive rats (SHR) on these transports were addressed using culture cells. A substantial activation in both Ca and Na pump was observed in VSMC of SHR compared to that of WKY. This difference may be caused by an increased Na-H antiport of SHR VSMC. In the presence of serum from SHR, there was a greater stimulation of Na-pump, which was originally triggered by the actiation of Na-H antiport. These evidences strongly suggest not only an abnormally increased membrane permeability of SHR cell membrane which is innate to SHR cells but also the involvement of some unknown humoral factors which elicits an activation of Na-pump followed by an activation of NA-H antiport.
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Report
(3 results)
Research Products
(24 results)