Basic development for practical use of Compton gamma-ray camera for next-generation nuclear medicine for development of new drugs

• Project/Area Number: 16K09022
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Medical Physics and Radiological Technology
• Research Institution: Tokai University
• Principal Investigator: KABUKI Shigeto 東海大学, 医学部, 講師 (00402777)
• Co-Investigator(Kenkyū-buntansha): 櫛田 淳子 東海大学, 理学部, 教授 (80366020) ; 西嶋 恭司 東海大学, 理学部, 教授 (40202238) ; 国枝 悦夫 東海大学, 医学部, 教授 (70170008)
• Research Collaborator: TANIMORI Toru
• Project Period (FY): 2016-04-01 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2018: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2017: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: ガンマ線カメラ / テクネチウム / コンプトンカメラ / 放射線計測 / 放射性薬剤 / 核医学 / コンプトンガンマ線カメラ / 創薬 / テクネシウム / 医学物理 / 核医学物理学

Outline of Final Research Achievements

In this research, basic development for practical use of electron-tracking Compton gamma-ray camera (ETCC) was done.As development necessary for practical use, compactification using the photodetector MPPC and the quantitative image reconstruction algorithm have been developed.
Also, Tc-95, a candidate nuclide for the new drug was imaged using ETCC.In the Tc-95 test, imaging was performed from two directions using a cylindrical phantom, and three-dimensional reconstruction was successfully performed using the developed image reconstruction algorithm. Through this research, more quantitative images of Tc-95 are obtained using the new algorithm, and our research has advanced.

Academic Significance and Societal Importance of the Research Achievements

本研究は従来の核医学用ガンマ線カメラに比べエネルギー計測範囲の広いガンマ線カメラの開発で、この特徴から様々な核種を用いた放射性薬剤の選択肢が増え、様々ながんを適切に診断できる可能性を広げる。更に半減期の長い核種を用いた抗体医薬品の開発や、マイクロドーズ臨床試験用の核種の自由な選択等、実用化後の臨床応用の幅は広い。本研究では新しい薬剤の候補地として、原子炉を用いて親核種が精製されるTc-99mの代替核種として提案されているTc-95の撮像試験にも成功した。Tc-95は原子力研究所で検討が進められており、加速器を用いて精製されるため環境に安全で今後の核医学検査にとっても非常に重要である。

Research Products

• [Journal Article] Data acquisition and image reconstruction of a radiation source assuming cancer tumor by Electron Tracking Compton Camera (2019)
  • Author(s): Shingo Uematsu, Junko Kushida, Kyoshi Nishijima, Shigeto Kabuki, Etsuo Kunieda, Yuichi Hatsukawa
  • Journal Title: Proc. Sch. Sci. TOKAI UNIV. Volume: 54 Pages: 37-54
  • NAID: 120006821806
  • Peer Reviewed
• [Journal Article] Electron-tracking Compton camera imaging of technetium-95m (2018)
  • Author(s): Hatsukawa Y, Hayakawa T, Tsukada K, Hashimoto K, Sato T, Asai M, Toyoshima A, Tanimori T, Sonoda S, Kabuki S, Kimura H, Takada A,
  • Journal Title: PLOSONE Volume: 13 Issue: 12 Pages: e0208909-e0208909
  • DOI: 10.1371/journal.pone.0208909
  • NAID: 120007185889
  • Peer Reviewed / Open Access
• [Presentation] Basic study of prompt gamma-ray imaging under the proton beam irradiation field using an electron-tracking Compton camera (2018)
  • Author(s): Shigeto Kabuki,, Jun Yamashita, Sodai Tanaka, Masato Tsuneda, Tsukasa Aso, Haruo Yamashita, Etsuo Kunieda, Toru Tanimori, Teiji Nishio
  • Organizer: ECR2018
  • Int'l Joint Research
• [Presentation] 電子飛跡コンプトンカメラを用いた95-Tcの画像化試験 (2018)
  • Author(s): 株木重人,初川雄一,高木 章,中村圭吾,櫛田淳子,塚田和明,浅井雅人,豊嶋厚史,高田淳史,水本哲也,園田信也,西嶋恭司,谷森達,國枝悦夫
  • Organizer: 第116回日本医学物理学会学術大会
• [Presentation] Basic study of prompt gamma-ray imaging under the proton beam irradiation field using an electron-tracking Compton camera (2018)
  • Author(s): Shigeto Kabuki, Jun Yamashita, Sodai Tanaka, Masato Tsuneda, Tsukasa Aso, Haruo Yamashita, Etsuo Kunieda, Toru Tanimori, Teiji Nishio
  • Organizer: ECR 2018
  • Int'l Joint Research
• [Presentation] Basic Study and Improvements of Electron-Tracking Compton Camera for Practical Use (2017)
  • Author(s): S. Kabuki, S. Fujii, T. Nagakura, J. Yamashita, J. Kushida, K. Nishijima, A. Takada, T. Mizumoto, Y. Mizumura, T. Tanimori and E. Kunieda
  • Organizer: AAPM 2017
  • Int'l Joint Research
• [Presentation] 電子飛跡検出型コンプトンカメラを用いた陽子線照射時の即発ガンマ線画像化の基礎試験 (2017)
  • Author(s): 株木重人、山下詢、田中創大、恒田雅人、高田淳史、水本哲矢、水村好貴、國枝悦夫、谷森達、西尾禎治
  • Organizer: 日本放射線腫瘍学会 第３０回学術大会
• [Presentation] Consideration of miniaturization and detection accuracy improvement of Electron -Tracking Compton Camera (2016)
  • Author(s): S. Fujii, S. Takano, J. Yamashita, S. Kabuki , J. Kushida, K. Nishijima, A. Takada3, T. Mizumoto, Y. Mizumura, T. Tanimori E. Kunieda
  • Organizer: 第112回 医学物理学会
  • Place of Presentation: 沖縄コンベンションセンター（沖縄県宜野湾市）
  • Year and Date: 2016-09-10