Novel Therapeutics for Vascular Calcification

• Project/Area Number: 16K09655
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Kidney internal medicine
• Research Institution: Keio University
• Principal Investigator: Tadashi Yoshida 慶應義塾大学, 医学部(信濃町), 准教授 (00306713)
• Research Collaborator: HAYASHI Matsuhiko ; YAMASHITA Maho ; HORIMAI Chihiro
• Project Period (FY): 2016-04-01 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 血管石灰化 / 慢性腎臓病 / 慢性腎不全

Outline of Final Research Achievements

Vascular calcification is highly prevalent in patients with chronic kidney disease. The aim of the present study was to determine the role of pro-inflammatory nuclear factor-kB signaling for vascular calcification in chronic kidney disease. We found that the nuclear factor-kB signaling in vascular smooth muscle cells plays an important role in phosphate-induced vascular calcificaton in chronic kidney disease.

Academic Significance and Societal Importance of the Research Achievements

慢性腎臓病における血管石灰化は、心血管イベントを引き起こす原因となる。しかし、現在のところ血管石灰化の有効な治療薬は存在しない。今回の研究では、慢性腎臓病においては、血管平滑筋におけるNF-kB活性が血管石灰化に重要な役割を果たしていることを明らかにした。血管平滑筋においてNF-kBを制御することが、新たな治療法となる可能性を示した。

Research Products

• [Journal Article] Smooth muscle-selective nuclear factor-kB inhibition reduces phosphate-induced arterial medial calcification in mice with chronic kidney disease (2017)
  • Author(s): Tadashi Yoshida, Maho Yamashita, Chihiro Horimai, Matsuhiko Hayashi
  • Journal Title: Journal of the American Heart Association Volume: 6
  • Peer Reviewed / Open Access
• [Journal Article] Podocyte-specific NF-kB inhibition ameliorates proteinuria in adriamycin-induced nephropathy in mice (2017)
  • Author(s): Maho Yamashita, Tadashi Yoshida, Sayuri Suzuki, Koichiro Homma, Matsuhiko Hayashi
  • Journal Title: Clinical and Experimental Nephrology Volume: 21 Pages: 16-26
  • Peer Reviewed
• [Journal Article] Pleiotropic effets of statins on acute kidney injury: involvement of Kruppel-like factor 4 (2017)
  • Author(s): Tadashi Yoshida, Matsuhiko Hayashi
  • Journal Title: Clinical and Experimental Nephrology Volume: 21 Issue: 2 Pages: 175-181
  • DOI: 10.1007/s10157-016-1286-4
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Podocyte NF-ｋB is dispensable for the pathogenesis of renal ischemia-reperfusion injury (2017)
  • Author(s): Maho Yamashita, Tadashi Yoshida, Matsuhiko Hayashi
  • Journal Title: Physiological Reports Volume: 4 Issue: 16 Pages: e12912-e12912
  • DOI: 10.14814/phy2.12912
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Presentation] NF-kB in smooth muscle cells plays a key role in arterial medial calcification in chornic kidney disease (2018)
  • Author(s): Tadashi Yoshida, Maho Yamashita, Matsuhiko Hayashi
  • Organizer: ISN (International Society of Nephrology) Frontiers Meeting 2018
  • Int'l Joint Research
• [Presentation] NF-kB in smooth muscle cells plays a key role in arterial medial calcification in chornic kidney disease (2017)
  • Author(s): Tadashi Yoshida, Maho Yamashita, Matsuhiko Hayashi
  • Organizer: ISN Frontiers Meeting 2018
  • Int'l Joint Research
• [Presentation] Smooth musle-selective NF-kB inhibition reduces phosphate-induced vascular calcification in mice with chornic kidney disease (2017)
  • Author(s): Tadashi Yoshida, Maho Yamashita, Matsuhiko Hayashi
  • Organizer: 54th ERA-EDTA (European Renal Association-European Dialysis and Transplant Association) Congress
  • Int'l Joint Research
• [Book] Encyclopedia of Signaling Molecules, 2nd Edition (2018)
  • Author(s): Tadashi Yoshida
  • Total Pages: 6060
  • Publisher: Springer
  • ISBN: 9783319671987