Immunoregulation with the view of the development of a novel vaccine for the prevention of dental caries.
| Project/Area Number |
16K15792
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pathobiological dentistry/Dental radiology
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| Research Institution | Fukuoka Dental College |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
永尾 潤一 福岡歯科大学, 口腔歯学部, 講師 (30509047)
成田 由香 福岡歯科大学, 口腔歯学部, 助教 (50758050)
長 環 福岡歯科大学, 口腔歯学部, 教授 (90131870)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 歯学 / 免疫学 / 微生物学 / 細菌 / 細胞・組織 / 微生物 |
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| Outline of Final Research Achievements |
Dental caries are infectious diseases caused by paticular pathogenetic bacteria resident in the oral cavity. Prevention of dental caries is nothing less than preventing these bacteria from adhering to tooth surfaces. Antibodies are contained in saliva and caries can be prevented by them if it can increase the amount of antibodies targeting these bacteria. In this study, we focused on T cells and explored the epitopes of pathogenetic bacteria, aiming at the development of vaccines to prevent dental caries. Thus, this research is expected to develop into the development of a new-generation vaccine for dental caries prevention.
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Report
(3 results)
Research Products
(29 results)
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[Journal Article] The transcription factor EPAS1 links DOCK8 deficiency to atopic skin inflammation via IL-31 induction.2017
Author(s)
Yamamura K, Uruno T, Shiraishi A, Tanaka Y, Ushijima M, Nakahara T, Watanabe M, Kido-Nakahara M, Tsuge I, Furue M, Fukui Y.
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Journal Title
Nat Commun.
Volume: 8
Pages: 13946-13946
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Antifungal activity in vitro and in vivo of a salmon protamine peptide and its derived cyclic peptide against Candida albicans.2017
Author(s)
Nagao, J., Cho, T., Mitarai, M., Iohara, K., Hayama, K., Abe, S. and Tanaka, Y.
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Journal Title
FEMS Yeast Res
Volume: 17
DOI
Related Report
Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
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[Presentation] A novel alternative splicing of T-cell signaling molecule modulates TCR-mediated responses in Th2 cells.2017
Author(s)
Ikezaki, S., Nagao, J., Hashimoto, M., Tasaki, S.，Yasumatsu, K., Toyoda, K., Narita, Y., Arita-Morioka, K, Cho, T, Tanaka Y.
Organizer
The 47th Annual Meeting of The Japanese Society for Immunology.
Related Report
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[Presentation] Role of a novel immune signaling molecule in Th2-type response.2016
Author(s)
Hashimoto, M., Nagao, J., Ikezaki, S., Tasaki, S., Narita, Y., Arita (Morioka), K., Yasumatsu, K., Cho, T., Yuasa, K., Tanaka, Y.
Organizer
The 45th Annual Meeting of The Japanese Society for Immunology.
Place of Presentation
Okinawa
Year and Date
2016-12-05
Related Report
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[Presentation] Investigation of the mechanism of T cell response in oral candidasis.2016
Author(s)
Tasaki, S., Cho, T., Nagao, J., Narita, Y., Hashimoto, M., Ikezaki, S., Yasumatsu, K., Arita (Morioka), K., Kojima, H., Tanaka, Y.
Organizer
The 45th Annual Meeting of The Japanese Society for Immunology.
Place of Presentation
Okinawa
Year and Date
2016-12-05
Related Report
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