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Establishment of novel bone regeneration therapy utilizing combination of multiple growth factors not susceptible to inflammatory mediator

Research Project

Project/Area Number 16K21308
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Dental engineering/Regenerative dentistry
Prosthodontics/ Dental materials science and
Research InstitutionIwate Medical University

Principal Investigator

Yokota Jun  岩手医科大学, 歯学部, 助教 (60733730)

Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords骨再生法 / サイトカイン / BMP-2 / 炎症性刺激 / 炎症性サイトカイン / MSC / 成長因子 / PDGF / TGF-b / TGF-β / 歯顎
Outline of Final Research Achievements

Bone morphogenic proteins (BMPs) is reported that the most effective factor for promoting proliferation and differentiation for osteoblast when assuming bone regeneration therapy. However, it has been clarified that BMP is not expected a satisfactory bone formation reaction, because of inflammatory reaction with surgical treatment in vivo.
Therefore, we attempt to establish novel bone regeneration therapy utilizing combination of multiple growth factors which having an acting mechanism different from BMP signal pathway.

Academic Significance and Societal Importance of the Research Achievements

BMP-2は細胞内シグナル系を介して顕著に骨芽細胞へと分化させるが、実際の骨欠損部や外科的侵襲を受けた組織には一時的な炎症反応が起き、様々な炎症性サイトカイン産生が誘導されることで、局所の細胞増殖、分化に関わり、創傷治癒ならびに骨形成に重大な影響を及ぼす。とくにこれらの炎症性刺激はBMP-2に関係するシグナル系の活性化を阻害して骨芽細胞分化ならびに骨形成を抑制することがわかっている。本研究で着目しているBMP以外の複数の成長因子を組み合わせて用いた炎症反応に影響されない骨再生技術確立の試みについては未だ報告がなく、臨床応用可能で画期的な骨再生技術の確立に繋がる可能性が高い。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (9 results)

All 2018 2017 2016

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (8 results) (of which Int'l Joint Research: 2 results)

  • [Journal Article] Effects of Addition of Nano-hydroxyapatite to Highly-pressed Collagen on Osteogenic Differentiation in Osteoblastic SaOS-2 Cells2016

    • Author(s)
      Koji IKEDA, Masayuki TAIRA, Jun YOKOTA, Masayuki HATTORI, Akira ISHISAKI, and Hisatomo KONDO
    • Journal Title

      Nano Biomedicine

      Volume: 8 Pages: 91-100

    • NAID

      130005243671

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Presentation] 口腔内スキャナーを用いたジルコニア製上部構造と対合歯の咬耗に関する客観的評価2018

    • Author(s)
      福徳 暁宏,田邉 憲昌,塚谷 顕介,折祖 研太,横田 潤,齋藤 裕美子,野尻 俊樹,近藤 尚知
    • Organizer
      第48回日本口腔インプラント学会学術大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 自家骨移植における骨再生の細胞動態の解析2017

    • Author(s)
      井上学、横田潤、高藤恭子、近藤尚知
    • Organizer
      第14回日本再生歯科医学会 総会・学術大会
    • Place of Presentation
      北海道
    • Year and Date
      2017-02-24
    • Related Report
      2016 Research-status Report
  • [Presentation] Effects of physicochemical properties of anodized hydrothermally treated titanium on in mesenchymal stem cell lines derived from the bone marrow mice2017

    • Author(s)
      YOKOTA J、KONDO H.
    • Organizer
      ITI World Symposium
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] 炎症性刺激に影響されない複数の成長因子による骨芽細胞分化効果2017

    • Author(s)
      横田潤、畠山航、池田功司、菅原志帆、石崎明、近藤尚知
    • Organizer
      第47回公益社団法人日本口腔インプラント学会学術大会
    • Related Report
      2017 Research-status Report
  • [Presentation] Roles of TGF-β and VEGF on efficient bone formation by mesenchymal stem cells2016

    • Author(s)
      YOKOTA J, MIURA S, KIHARA H, HATAKEYAMA W, KONDO H
    • Organizer
      第20回 公益社団法人日本学顔面インプラント学 会総会・学術大会
    • Place of Presentation
      東京
    • Year and Date
      2016-12-03
    • Related Report
      2016 Research-status Report
  • [Presentation] Clinical evaluation of sinus floor elevation using the plate shaped bone substitute2016

    • Author(s)
      Kyoko Takafuji,Hidemichi Kihara,Wataru Hatakeyama,Jun Yokota,Hisatomo Kondo
    • Organizer
      EAO congress 2016
    • Place of Presentation
      Paris, France
    • Year and Date
      2016-09-27
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] 7 Tesla超高磁場MRIにおけるジルコニア含有インプラントと純Tiインプラントの影響の比較2016

    • Author(s)
      折祖研太,小林琢也,久保田将史,横田潤,玉田泰嗣,野村太郎,,鬼原英道,近藤尚知
    • Organizer
      第46回公益社団法人日本口腔インプラント学会学術大会
    • Place of Presentation
      名古屋
    • Year and Date
      2016-09-16
    • Related Report
      2016 Research-status Report
  • [Presentation] 赤色蛍光強発現遺伝子導入マウスを用いた骨欠損部における移植骨周囲組織の治癒機構の解析2016

    • Author(s)
      井上学,横田 潤,西尾俊彦,松原大,高藤恭子,鬼原英道,石崎明,近藤尚知
    • Organizer
      第36回(公社)日本口腔インプラント学会 東北・北海道支部 総会・学術大会
    • Place of Presentation
      岩手
    • Year and Date
      2016-07-02
    • Related Report
      2016 Research-status Report

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Published: 2016-04-21   Modified: 2020-03-30  

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