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Chemistry of radioactive radon for developing an astatine -211 generator system

Research Project

Project/Area Number 17K05807
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Inorganic chemistry
Research InstitutionKanazawa University

Principal Investigator

YOKOYAMA AKIHIKO  金沢大学, 物質化学系, 教授 (80230655)

Co-Investigator(Kenkyū-buntansha) 鷲山 幸信  福島県立医科大学, 公私立大学の部局等, 准教授 (80313675)
Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2017: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywordsアスタチン / ラドン / ジェネレータ / 溶媒抽出 / イオン液体 / ポロニウム / NBS / NCS / 原子・分子物理 / 放射線 / ジェネレーター / 反応・分離工学
Outline of Final Research Achievements

Present study using a TLC chromatography enabled us to analyze At species and know its correlation to extraction behaviors. It underlines the importance of oxidation states of At based on a quantitative discussion. A radon-gas storage method was devised in this study to construct an isolation process between radon and astatine by using extraction into ion liquid with a high separation factor, that is, least contamination of radon. Removal of polonium, a by-product of radon was also made possible with a cation-exchange resin. The study enables one to construct a proto-type generator of astatine from its parent nuclide of radon.

Academic Significance and Societal Importance of the Research Achievements

本研究は、がん細胞抑制に有効な「標的α線治療」に利用できるアスタチン-211核種の化学的な研究である。アスタチン-211は半減期が7.2時間と短く、また化学的な取扱いも方法もよく定まっていない。この研究では半減期の短さをアスタチン-211に壊変する別の核種であるラドン-211からミルキングという手法で得ることで緩和し、また一連の化学操作手順について構築することで、実際の利用に向けた道筋をつけるものである。とくに身近にあるにもかかわらず、化学的取り扱いが難しいラドン元素の化学的な扱いにスポットを当てている。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report

Research Products

(17 results)

All 2020 2019 2018 2017

All Journal Article (3 results) (of which Peer Reviewed: 2 results,  Open Access: 2 results) Presentation (14 results) (of which Int'l Joint Research: 5 results,  Invited: 4 results)

  • [Journal Article] Current Status of alpha emitters useful for targeted radionuclide therapy2020

    • Author(s)
      鷲山幸信
    • Journal Title

      DDS

      Volume: 35 Issue: 2 Pages: 102-113

    • DOI

      10.2745/dds.35.102

    • NAID

      130007864108

    • ISSN
      0913-5006, 1881-2732
    • Related Report
      2019 Annual Research Report
    • Open Access
  • [Journal Article] Speciation analysis of oxidation states of astatine extracted into ethanol-water solutions2019

    • Author(s)
      Y. Shin, K. Kawasaki, K. Aoi, K. Washiyama, A. Yokoyama, I. Nishinaka, S. Yanou, and H. Haba
    • Journal Title

      RIKEN accelerator progress report

      Volume: 52 Pages: 204-204

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Dissolved state of radon with cluster molecules of solvent2018

    • Author(s)
      N. Yamada, Y. Shin, K. Kawasak, A. Yokoyama, T. Ida
    • Journal Title

      Journal of Radioanalytical and Nuclear Chemistry

      Volume: 318 Pages: 2303-2306

    • DOI

      10.1007/s10967-018-6223-4

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Presentation] Rn-211/At-211 ジェネレータシステムに必要な207Po 除去法の検討2019

    • Author(s)
      青井 景都, 新 裕貴, 川﨑 康平, 東 美里, 鷲山 幸信, 西中 一朗, 羽場 宏光, 森 大輝, Yang Wang, 横山 明彦
    • Organizer
      日本放射化学会第63回討論会
    • Related Report
      2019 Annual Research Report
  • [Presentation] ラドンの気相回収法とイオン液体抽出によるRn-At ジェネレーターシステムの開発2019

    • Author(s)
      川﨑 康平, 新 裕貴, 青井 景都, 東 美里, 鷲山 幸信, 西中 一朗, 横山 明彦
    • Organizer
      日本放射化学会第63回討論会
    • Related Report
      2019 Annual Research Report
  • [Presentation] アルファ放射体を用いた標的アイソトープ治療(TRT)2019

    • Author(s)
      鷲山幸信
    • Organizer
      日本医学物理学会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] An effort to diagnostic and therapeutic nuclear medicine at Fukushima Medical University using two medical cyclotrons2019

    • Author(s)
      Kohshin Washiyama
    • Organizer
      International Symposium on Trends in Radiopharmaceuticals (ISTR-2019)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] An effort to diagnostic and therapeutic nuclear medicine at Fukushima Medical University towards the clinical trials2019

    • Author(s)
      Kohshin Washiyama
    • Organizer
      KIRAMS International Symposium on Theranostics: Radioisotopes and Clinical Practice
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Development and challenges of alpha-emitting radiopharmaceuticals2019

    • Author(s)
      Kohshin Washiyama
    • Organizer
      Korean Society of Radiopharmaceutical and Molecular Probes 2019
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] アルファ放射体を用いた内用療法への取り組み2019

    • Author(s)
      鷲山幸信
    • Organizer
      日本核医学会分科会放射性薬品科学研究会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] TLC, IPを用いた溶液中でのアスタチンの化学種同定2019

    • Author(s)
      丸山峻平、横山明彦、西中一朗、鷲山幸信、川﨑康平、青井景都、東美里
    • Organizer
      日本化学会近畿支部2019年度北陸地区講演会と研究発表会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 211Rn-211At ジェネレータ開発のためのアスタチン溶媒抽出研究 ―131 Iとの抽出挙動の比較及び酸化剤効果の調査―2018

    • Author(s)
      新 裕喜,川崎 康平,青井 景都,横山 明彦,鷲山 幸信, 西中 一朗,矢納 慎也 ,羽場 宏光
    • Organizer
      2018日本放射化学会年会・放射化学討論会
    • Related Report
      2018 Research-status Report
  • [Presentation] ラドンガス密封シリンジを利用した Rn-Atジェネレーターシステムの開発2018

    • Author(s)
      川﨑 康平, 新 裕喜, 青井 景都, 鷲山 幸信, 西中 一朗, 羽場 宏光, 矢納 慎也, 横山 明彦
    • Organizer
      2018日本放射化学会年会・放射化学討論会
    • Related Report
      2018 Research-status Report
  • [Presentation] Dissolved state of radon with cluster molecules of solvent2018

    • Author(s)
      N. Yamada, Y. Shin, K. Kawasak, A. Yokoyama, T. Ida
    • Organizer
      the 18th Radiochemical conference
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] 211Rn-211At ジェネレーター開発のためのアスタチン溶媒抽出の研究2017

    • Author(s)
      新 裕喜、川﨑 康平、山田 記大、横山 明彦、鷲山 幸信、西中 一朗
    • Organizer
      2017日本放射化学会年会 第61回放射化学討論会
    • Related Report
      2017 Research-status Report
  • [Presentation] Wet chemistry of radon and astatine for the development of a 211Rn/211At generator2017

    • Author(s)
      Y. Shin, S. Ooe, K. Murakami, T. Taniguchi, E. Maeda, N. Yamada, K. Washiyama, A. Yokoyama, I. Nishinaka
    • Organizer
      10th International Symposium on Targeted Alpha Therapy
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Development of a 211Rn/211At Generator Using a Wet Chemistry Approach for Targeted Alpha Therapy Applications2017

    • Author(s)
      Yuki SHIN, Akihiko YOKOYAMA, Shuta OOE, Kento MURAKAMI, Takumi TANIGUCHI, Eita MAEDA, Norihiro YAMADA, Kohshin WASHIYAMA, Ichiro NISHINAKA
    • Organizer
      6th Asia-Pacific Symposium on Radiochemistry
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research

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Published: 2017-04-28   Modified: 2021-02-19  

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