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Functional analysis of BMP binding protein, Cv2, in nephorogenesis

Research Project

Project/Area Number 21770249
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Developmental biology
Research InstitutionKyoto University

Principal Investigator

IKEYA Makoto  Kyoto University, 再生医科学研究所, 研究員 (20442923)

Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2009: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Keywords遺伝学 / 発生・分化 / 細胞・組織 / シグナル伝達 / 循環器・高血圧
Research Abstract

The fine-tuning of BMP signals is critical for many aspects of complex organogenesis. We show that the augmentation of BMP signaling by a BMP-binding secreted factor, Crossveinless2 (Cv2), is essential for the early embryonic development of mammalian nephrons and also that Cv2 exerts its pro-BMP nephrogenic function Tsg- dependently. We published these findings in the journal "Develpmental Biology".

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (8 results)

All 2010 2009

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (4 results) Book (2 results)

  • [Journal Article] Cv2, functioning as a pro-BMP factor via twisted gastrulation, is required for early development of nephron precursors.2010

    • Author(s)
      Ikeya M, et al.
    • Journal Title

      Developmental Biology Vol 337

      Pages: 405-414

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cv2, functioning as a pro-BMP factor via twisted gastrulation, is required for early development of nephron precursors2010

    • Author(s)
      Ikeya M, et al.
    • Journal Title

      Developmental Biology

      Volume: 337 Pages: 405-414

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] Tsg依存的BMP促進因子Cv2は、ネフロン前駆体の凝集を制御する2009

    • Author(s)
      池谷真, 他
    • Organizer
      第42回日本発生生物学会大会
    • Place of Presentation
      新潟
    • Year and Date
      2009-05-30
    • Related Report
      2010 Final Research Report
  • [Presentation] Tsg依存的BMP促進因子Cv2は、ネフロン前駆体の凝集を制御する2009

    • Author(s)
      池谷真, 他
    • Organizer
      第42回日本発生生物学会大会
    • Place of Presentation
      朱鷺メッセ 新潟コンベンションセンター(新潟県)
    • Year and Date
      2009-05-30
    • Related Report
      2009 Annual Research Report
  • [Presentation] Cv2 is required for early nephron development as a pro-BMP factor functioning via Twisted gastrulation2009

    • Author(s)
      池谷真, 他
    • Organizer
      日本分子生物学会第9回春期シンポジウム
    • Place of Presentation
      宮崎
    • Year and Date
      2009-05-11
    • Related Report
      2010 Final Research Report
  • [Presentation] Gv2 is required for early nephron development as a pro-BMP factor functioning via Twisted gastrulation2009

    • Author(s)
      池谷真, 他
    • Organizer
      日本分子生物学会第9回春季シンポジウム
    • Place of Presentation
      シーガイア ワールドコンベンションセンター・サミット(宮崎県)
    • Year and Date
      2009-05-11
    • Related Report
      2009 Annual Research Report
  • [Book] Gatewayを用いた遺伝子導入マニュアル(第6章)2009

    • Author(s)
      池谷真, 他
    • Publisher
      シュプリンガー・ジャパン株式会社
    • Related Report
      2010 Final Research Report
  • [Book] Gatewayを用いた遺伝子導入マニュアル 第6章(p75-86)2009

    • Author(s)
      池谷真, 他
    • Total Pages
      12
    • Publisher
      シュプリンガー・ジャパン株式会社
    • Related Report
      2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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