Development of Bioactive Heterocycles by Tin-Free C1 Introduction Radical Process
| Project/Area Number |
21790013
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Chemical pharmacy
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| Research Institution | Kyoto University |
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Principal Investigator |
YAMADA Kenichi 京都大学, 大学院・薬学研究科, 准教授 (00335184)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | ラジカル / C1単位 / 生理活性物質 / 複素環構築 / 環境調和 |
|---|
| Research Abstract |
Development of tin-free radical process is an important research field because of the indispensable utility of radical reactions and the toxicity of tin reagents. We have already developed dimethylzinc-and triethylborane-mediated tin-free radical processes. During this research project to increase the scope of our process, we found the acceleration effect of ferric chloride, an interesting reaction switching of alkylidenemalonate, efficient radical accepting ability of N-alkoxycarbonyl-imine, and isocyanate forming reaction of the imine.
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Report
(4 results)
Research Products
(82 results)
