• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Toxicogenomic analysis of pyrroloquinoline quinone of vitamin-like compound

Research Project

Project/Area Number 21790550
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Hygiene
Research InstitutionUniversity of the Ryukyus

Principal Investigator

TACHIBANA Shinjiro  琉球大学, 農学部, 准教授 (70447655)

Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Keywordsピロロキノリンキノン / ビタミン / マイクロアレイ / トキシコゲノミクス / 骨粗鬆症 / 骨芽細胞
Research Abstract

In this study, we analyzed cytotoxicity and gene expression during osteogenesis by addition of pyrroloquinoline quinone(PQQ) showing vitamin-like bioactivity on murine osteoblast. The osteoblast treated with PQQ showed cytotoxicity and growth inhibition at the concentration of 0. 1 mM. During osteogenesis after differentiation, the presence of PQQ increases the enzyme activity of alkaline phosphatase known as the marker enzyme of the osteogenesis, although the osteoblast exhibited the decreasing of mineralization along with the concentration-dependent of PQQ.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (2 results)

All Other

All Remarks (2 results)

  • [Remarks] 琉球大学研究者データベース

    • URL

      http://www.jim.u-ryukyu.ac.jp/kenkyushadb/index.html

    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://www.agr.u-ryukyu.ac.jp/wp/tachiban

    • Related Report
      2010 Annual Research Report

URL: 

Published: 2009-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi