A possible role of gadolinium on fibrosis and calcification in nephrogenic systemic fibrosis

• Project/Area Number: 21791061
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Dermatology
• Research Institution: Gunma University
• Principal Investigator: OKADA Etsuko Gunma University, 医学部, 助教 (90334094)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000); Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: ガドリニウム / 腎性全身性線維症 / 石灰化 / 線維化 / 細胞

Research Abstract

Gadolinium induced calcium deposition in MC3T3-E1 cells, human adipose tissue-derived mesenchymal stem cells (HAMSCs) and human dermal fibroblasts(HDFs) in osteogenic differentiation media. Gadolinium did not increase the mRNA expression of type I collagen in HDFs, but did promote cell proliferation.
The result will help us to understand the mechanism of abnormal calcification in nephrogenic systemic fibrosis.

Research Products

• [Journal Article] (2011)
  • Author(s): Etsuko Okada, Masayoshi Yamanaka, Osamu Ishikawa
  • Journal Title: Journal of Dermatological Science vol62 Pages: 58-63
  • Peer Reviewed
• [Journal Article] New insights into the mechanism of abnormal calcification in nephrogenic systemic fibrosis-gadolinium promotes calcium deposition of mesenchymal stem cells and dermal fibroblasts (2011)
  • Author(s): E.Okada, M.Yamanama, O.Ishikawa
  • Journal Title: Journal of dermatological science Volume: 62 Pages: 58-63
  • NAID: 10030890935
  • Peer Reviewed
• [Presentation] 腎性全身性線維症の石灰化機序の検討 (2010)
  • Author(s): 岡田悦子, 山中正義, 石川治
  • Organizer: 第17回分子皮膚科学フォーラム
  • Place of Presentation: 福岡
• [Presentation] A possible role of gadolinium on fobrosis and calcification in nephrogenic systemic fibrosis (2009)
  • Author(s): E.OKADA, et al.
  • Organizer: 第34回日本研究皮膚科学会
  • Place of Presentation: 福岡県
  • Year and Date: 2009-12-06
• [Presentation] A possible role of gadolinium on fibrosis and calcification in nephrogenic systemic fihrncic (2009)
  • Author(s): Etsuko Okada, Masayoshi Yamanaka, Osamu Ishikawa
  • Organizer: 日本研究皮膚科学会第34回年次学術大会・総会
  • Place of Presentation: 福岡