A possible role of gadolinium on fibrosis and calcification in nephrogenic systemic fibrosis
| Project/Area Number |
21791061
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Dermatology
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| Research Institution | Gunma University |
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Principal Investigator |
OKADA Etsuko Gunma University, 医学部, 助教 (90334094)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | ガドリニウム / 腎性全身性線維症 / 石灰化 / 線維化 / 細胞 |
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| Research Abstract |
Gadolinium induced calcium deposition in MC3T3-E1 cells, human adipose tissue-derived mesenchymal stem cells (HAMSCs) and human dermal fibroblasts(HDFs) in osteogenic differentiation media. Gadolinium did not increase the mRNA expression of type I collagen in HDFs, but did promote cell proliferation.
The result will help us to understand the mechanism of abnormal calcification in nephrogenic systemic fibrosis.
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Report
(3 results)
Research Products
(5 results)
