/The analysis of the interaction between Streptococcus pneumoniae and human neutrophil.
Project/Area Number |
21890135
|
Research Category |
Grant-in-Aid for Research Activity Start-up
|
Allocation Type | Single-year Grants |
Research Field |
Orthodontic/Pediatric dentistry
|
Research Institution | Osaka University |
Principal Investigator |
MORI Yuka Osaka University, 歯学部附属病院, 医員 (90527227)
|
Project Period (FY) |
2009 – 2010
|
Project Status |
Completed (Fiscal Year 2010)
|
Budget Amount *help |
¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2010: ¥1,235,000 (Direct Cost: ¥950,000、Indirect Cost: ¥285,000)
Fiscal Year 2009: ¥1,365,000 (Direct Cost: ¥1,050,000、Indirect Cost: ¥315,000)
|
Keywords | Streptococcus pneumoniae / 肺炎球菌 / 自然免疫 / 好中球 / 菌体表層タンパク質 / Enolase / 遊走活性 / Neutrophil extracellular traps / Streptococcus pueumoniae / Neutrophil extraccllular traps |
Research Abstract |
Streptococcus pneumoniae is the common causative agent of community acquired pneumonia, otitis media, and sepsis. A major feature of pneumococcal pneumonia is an abundant neutrophil infiltration. Here, we identified S. pneumoniae Enolase as a neutrophil binding protein using ligand blot assay and mass spectrometry. Scanning electron microscopic and fluorescence microscopic analysis revealed S. pneumoniae Enolase induced the formation of neutrophil extracellular traps which was reported to bind and kill microbes extracellularly.
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Report
(3 results)
Research Products
(5 results)