Effect of lipid cytokine on arthritis

• Project/Area Number: 23592226
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Orthopaedic surgery
• Research Institution: Osaka City University
• Principal Investigator: KOIKE Tatsuya 大阪市立大学, 医学(系)研究科(研究院), 教授 (50271177)
• Co-Investigator(Kenkyū-buntansha): EBIHARA Ken 京都大学, 大学院医学研究科, 准教授 (70362514) ; TADA Masahiro 大阪市立大学, 大学院医学研究科, 病院講師 (20514235)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 肥満 / 炎症 / レプチン / マウス / 関節炎 / トランスジェニック

Research Abstract

Among rheumatoid arthritis patients, fatty patients show relatively low inflammation. So we thought that leptin derived from fat tissue might reduce the inflammation. At first ob/ob mouse, which has no leptin in the body, did not show any kind of arthritis induced by anti-collagen antibody. Next we created acquired leptin resistance mice by high fat diet. They got higher leptin concentration and showed lower grade of arthritis induced by anti-collagen antibody. At last, we could not induce arthritis in leptin transgenic mice, which showed hyperleptinemia. Finally we found that leptin decreased the production of IL-6, pro-inflammatory cytokine. Hyperleptinemia reduces inflammation.

Research Products

• [Journal Article] Nucleated cells circulating in the peripheral blood contribute to the repair of osteochondral defects only in the early phase of healing (2013)
  • Author(s): Okano T., Wakitani S., Okabe T., Takahashi M., Koike T., Nakamura H.
  • Journal Title: J Tissue Eng Regen Med Volume: in press Issue: 5 Pages: 414-420
  • DOI: 10.1002/term.1536
  • Peer Reviewed
• [Journal Article] Risk factors for severe nonsteroidal anti-inflammatory drug-induced small intestinal damage (2013)
  • Author(s): T. Watanabe, T. Tanigawa, Y. Nadatani, Y. Nagami, S. Sugimori, H. Okazaki, H. Yamagami, K. Watanabe, K. Tominaga, Y. Fujiwara, T. Koike, T. Arakawa
  • Journal Title: Digest Liver Dis Volume: in press Issue: 5 Pages: 390-395
  • DOI: 10.1016/j.dld.2012.12.005
  • Peer Reviewed
• [Journal Article] Acquired leptin resistance by high-fat feeding reduces inflammation from collagen antibody-induced arthritis in mice (2012)
  • Author(s): Sugioka Y, Okano T, Tada M, Nakamura H, Koike T
  • Journal Title: Clin Exp Rheumatol Volume: 30 Pages: 707-707
  • Peer Reviewed
• [Journal Article] Comparison of joint destruction between standard- and low-dose etanercept in rheumatoid arthritis from the Prevention of Cartilage Destruction by Etanercept (PRECEPT) study (2012)
  • Author(s): Masahiro Tada, Tatsuya Koike, Tadashi Okano, Yuko Sugioka, Shigeyuki Wakitani, Kenzo Fukushima, Akira Sakawa, Kazunori Uehara, Kentaro Inui and Hiroaki Nakamura
  • Journal Title: Rheumatology Volume: 51 Pages: 2164-9
  • Peer Reviewed
• [Journal Article] Acquired leptin resistance by high-fat feeding reduces inflammation from collagen antibody-induced arthritis in mice. (2012)
  • Author(s): Sugioka Y., Okano T., Tada M., Nakamura H., Koike T.
  • Journal Title: Clinical and Experimental Rheumatology. Volume: in press
  • Peer Reviewed
• [Journal Article] Efficacy of infliximab therapy for a patient with superficial thrombophlebitis and rheumatoid arthritis. (2011)
  • Author(s): Tada M., Fukai K., Okano T., Sugioka Y., Wakitani S., Nakamura H., Koike T.
  • Journal Title: International Journal of Clinical Medicine Volume: 2 Pages: 459-462
  • Peer Reviewed
• [Presentation] Hyoerleptinemia suppresses aggravation of arthritis of collagen antibody-induced arthritis in mice (2014)
  • Author(s): Okano T, Koike T, Inui K, Tada M, Sugioka Y, Mamoto K, Nakamura H
  • Organizer: Eular 2014
  • Place of Presentation: Paris (採択)
  • Year and Date: 2014-06-13
• [Presentation] VERY-HIGH-CONCENTRATION LEPTIN SUPPRESSES AGGRAVATION OF COLLAGEN ANTIBODY-INDUCED ARTHRITIS IN MICE (2014)
  • Author(s): Tadashi Okano, Tatsuya Koike, Yuko Sugioka, Masahiro Tada, Kenji Mamoto, Kentaro Inui, Hiroyuki Okihana, Ken Ebihara, Kazuwa Nakao, Hiroaki Nakamura
  • Organizer: Annual European Congress of Rheumatology EULAR 2014
  • Place of Presentation: Le Palais des Congress de Paris, Paris, France
• [Presentation] 高用量レプチンによって関節炎の重症化は抑制される (2012)
  • Author(s): 岡野匡志、小池達也、多田昌弘、杉岡優子、沖花裕行、中村博亮
  • Organizer: 第27回日本整形外科学会基礎学術総会
  • Place of Presentation: 名古屋
  • Year and Date: 2012-10-27
• [Presentation] 関節リウマチ患者においてレプチンの骨代謝、炎症に与える影響について (2011)
  • Author(s): 杉岡優子、脇谷滋之、真本建司、岡野匡志、多田昌弘、神山敦子、中村博亮、小池達也
  • Organizer: 第84回日本整形外科学会学術集会
  • Place of Presentation: 福岡
  • Year and Date: 2011-05-12
• [Presentation] Impact of adipocytokines on disease activity in rheumatoid arthritis patients - TOMORROW study- (2011)
  • Author(s): Sugioka Y., Wakitani S., Mamoto K., Okano T., Tada M., Nakamura H., Koike T.
  • Organizer: 2011 Annual European Congress of Rheumatology
  • Place of Presentation: London, United Kingdom
• [Presentation] Adipocytokines affect the bone metabolism of rheumatoid arthritis patients - TOMORROW study - (2011)
  • Author(s): Sugioka Y., Okano T., Tada M., Koike T.
  • Organizer: The 33rd Annual Meeting of American Society for Bone and Mineral Research
  • Place of Presentation: San Diego, Californis, USA
• [Presentation] Power Doppler signal Is frequently positive among patients with rheumatoid arthritis in clinical remission and normal serum matrix metalloproteinase-3 (MMP-3) levels
  • Author(s): Tadashi Okano, Tatsuya Koike, Masahiro Tada, Kenji Mamoto, Yuko Sugioka, Atsuko Kamiyama and Hiroaki Nakamura
  • Organizer: 76th American Collage of Rheumatology
  • Place of Presentation: Walter E. Washington Convention Center, Washington DC, USA
• [Presentation] Impact of disease activity on lipid profiles and adipocytokines in patients with rheumatoid arthritis -The TOMORROW study-
  • Author(s): Sugioka Y, Koike T, Mamoto K, Okano T, Tada M, Wakitani S, Nakamura H
  • Organizer: EULAR 2012
  • Place of Presentation: Messe Berlin, Berlin, Germany