| Project/Area Number |
25460738
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Epidemiology and preventive medicine
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| Research Institution | University of Tsukuba |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
Hamada Hiromi 筑波大学, 医学医療系, 教授 (60261799)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
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| Keywords | 早産 / 母児間免疫寛容 / 絨毛膜羊膜炎 / 予防戦略 / HLA-G |
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| Outline of Final Research Achievements |
Our aim was to develop a prevention strategy focused on maternal anti-fetal rejection for preterm delivery in women with chorioamnionitis. Although a considerable number of preterm deliveries are related to maternal anti-fetal rejection, we could not find evidence of their prevalence. We analyzed plasma soluble HLA-G levels in the first trimester of each of the 23 pregnant women. Owing to the limited number of cases, we could not establish the utility of plasma soluble HLA-G level in early pregnancy as an index marker of preterm delivery. We set the prevention protocol for preterm delivery, including screening for bacterial vaginosis and asymptomatic bacteriuria, measurement of uterine cervical length, and intervention with progesterone supplementation.
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