• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Molecular mechanisms of flexible decision making

Research Project

Project/Area Number 26290008
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Neurophysiology / General neuroscience
Research InstitutionUniversity of Yamanashi (2016)
Juntendo University (2014-2015)

Principal Investigator

UKA Takanori  山梨大学, 総合研究部, 教授 (50372933)

Research Collaborator SUDA Yuki  
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥16,120,000 (Direct Cost: ¥12,400,000、Indirect Cost: ¥3,720,000)
Fiscal Year 2016: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2015: ¥8,840,000 (Direct Cost: ¥6,800,000、Indirect Cost: ¥2,040,000)
Fiscal Year 2014: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords脳・神経
Outline of Final Research Achievements

Flexible decision making is a hallmark of human cognition. Subanesthetic dose of ketamine, an N-methyl-D-aspartate (NMDA) receptor antagonist, impairs such flexibility, but how it affects decision making circuits remains unclear. We recorded single unit activity in the lateral intraparietal area (LIP) while monkeys switched between a direction discrimination task and a depth discrimination task. Ketamine administration increased neural sensitivity to irrelevant information, and delayed the onset of decision-related neural activity. These results suggest that ketamine affected "what" information to process and "when" to process it.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • Research Products

    (7 results)

All 2016 2015 2014

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Acknowledgement Compliant: 1 results) Presentation (5 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Context-dependent accumulation of sensory evidence in the parietal cortex underlies flexible task switching.2016

    • Author(s)
      Kumano H, Suda Y, Uka T.
    • Journal Title

      J Neurosci

      Volume: 36 Issue: 48 Pages: 12192-12202

    • DOI

      10.1523/jneurosci.1693-16.2016

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Visual impairment by surrounding noise is due to interactions among stimuli in the higher-order visual cortex.2014

    • Author(s)
      Kumano H, Uka T
    • Journal Title

      J Neurophysiol

      Volume: 112 Issue: 3 Pages: 620-630

    • DOI

      10.1152/jn.00639.2013

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Presentation] NMDAR antagonist ketamine increases sensitivity to irrelevant information in the parietal cortex.2016

    • Author(s)
      Uka T, Suda Y.
    • Organizer
      第39回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜(神奈川県・横浜市)
    • Year and Date
      2016-07-20
    • Related Report
      2016 Annual Research Report
  • [Presentation] NMDAR antagonist ketamine affects sensitivity to irrelevant information and onset of build-up activity in the parietal cortex.2016

    • Author(s)
      Suda Y, Uka T.
    • Organizer
      Neuroscience 2016
    • Place of Presentation
      San Diego(アメリカ)
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Neural mechanisms of decision formation: Front-line research of perceptual and value-based decision making2015

    • Author(s)
      Uka T
    • Organizer
      第38回日本神経科学大会
    • Place of Presentation
      神戸
    • Year and Date
      2015-07-28
    • Related Report
      2015 Annual Research Report
  • [Presentation] Movement-specific employment of sensory signals as a basis for rapid task switching.2015

    • Author(s)
      Uka T, Sasaki R, Mitani A
    • Organizer
      第92回日本生理学会大会
    • Place of Presentation
      神戸
    • Year and Date
      2015-03-21 – 2015-03-23
    • Related Report
      2014 Annual Research Report
  • [Presentation] LIP neurons accumulate relevant information depending on task demand.2014

    • Author(s)
      Suda Y, Kumano H, Uka T
    • Organizer
      第36回日本神経科学大会
    • Place of Presentation
      横浜
    • Year and Date
      2014-09-11 – 2014-09-13
    • Related Report
      2014 Annual Research Report

URL: 

Published: 2014-04-04   Modified: 2018-03-22  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi