Molecular basis of immune receptor conferring dual resistance to virus and oomycete and its application for disease control
| Project/Area Number |
26292022
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Plant protection science
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
安藤 杉尋 東北大学, 農学研究科, 准教授 (10442831)
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| Project Period (FY) |
2014-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥15,990,000 (Direct Cost: ¥12,300,000、Indirect Cost: ¥3,690,000)
Fiscal Year 2017: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2016: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2015: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2014: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
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| Keywords | ウイルス / NB-LRRクラス抵抗性タンパク質 / エピジェネティクス / 病害抵抗性 / NB-LRRタンパク質 / ウィルス / 植物保護 / NB-LRR class Rタンパク質 / 植物病理 / ウイルス抵抗性 / キュウリモザイクウイルス / 病害抵抗性遺伝子 |
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| Outline of Final Research Achievements |
RCY1/HRT/RPP8 locus of Arabidopsis thaliana encodes NB-LRR class R-protein conferring the resistance to CMV, TCV and Hpa. The expression of RCY1/HRT/RPP8 locus was regulated by epigenetic modification through cytosine methylation of its promoter region, and accumulated level of R-protein was correlated with degree of disease resistance to pathogens. RCY1/HRT/RPP8 R-protein can recognize the molecular structure of multiple complex of CP mediated by N-terminal α-helix domain of CP.
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| Academic Significance and Societal Importance of the Research Achievements |
(1)抵抗性対立遺伝子座RCY1、HRT、RPP8は、エピジェネティックな調節により発現制御を受けていること、(2)同遺伝子座がコードするNB-LRRクラス抵抗性タンパク質の病原体認識にはLRRドメインが関わっていること、(3)同抵抗性タンパク質による認識される病原体分子（非病原力因子）の高次構造を明らかにした。これらの知見は抵抗性対立遺伝子座RCY1、HRT、RPP8による病害抵抗性の分子基盤の理解と、新規な病害防除方法への応用に寄与するものと考えられる。
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Report
(6 results)
Research Products
(35 results)
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[Journal Article] L-Histidine induces resistance in plants to the bacterial pathogen Ralstonia solanacearum partially through the activation of ethylene signaling.2016
Author(s)
Seo, S., Nakaho, K., Hong, S-W., Takahashi, H., Shigemori, H. and Mitsuhara, I.
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Journal Title
Plant Cell Physiology
Volume: 57
Pages: 1932-1942
DOI
Related Report
Peer Reviewed
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[Journal Article] Involvement of NtERF3 in the cell death signalling pathway mediated by SIPK/WIPK and WRKY1 in tobacco plants.2015
Author(s)
Ogata, T., Okada, H., Kawaide, H., Takahashi, H., Seo, S., Mitsuhara, I. and Matsushita, Y.
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Journal Title
Plant Biology
Volume: 17
Pages: 962-972
DOI
Related Report
Peer Reviewed
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[Journal Article] Transcriptional profile of tomato roots exhibiting Bacillus thuringiensis- induced resistance to Ralstonia solanacearum.2014
Author(s)
Takahashi, H., Nakaho, K., Ishihara, T., Ando, S., Wada, T., Kanayama, Y., Asano, S., Yoshida, S., Tsushima, S. and Hyakumachi, M.
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Journal Title
Plant Cell Reports
Volume: 33
Pages: 99-110
Related Report
Peer Reviewed / Acknowledgement Compliant
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