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2011 Fiscal Year Final Research Report

Immunological Self Recognition and its Disorders

Administrative Group

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Project AreaImmunological Self Recognition and its Disorders
Project/Area Number 19059009
Research Category

Grant-in-Aid for Scientific Research on Priority Areas

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionKyoto University

Principal Investigator

MINATO Nagahiro  京都大学, 医学研究科, 教授 (40137716)

Project Period (FY) 2007 – 2011
Keywords自己認識 / 免疫制御 / 胸腺 / 自己免疫病 / 炎症 / がん
Research Abstract

To understand the mechanisms of immunological self-recognition, we organized three research groups, (A01) basic immunological mechanisms, (A02) immunological diseases, (A03) new technological development for human immune system, and published over 1000 original scientific papers as a whole in the 5 year period. We also performed a series of educational courses for high school students to promote the interest and understanding of immunology as well as 4 open international symposia inviting world-leading immunologists. Ex post facto evaluation of the project by the MEXT biology committee was ranked “A”.

  • Research Products

    (29 results)

All 2012 2011 2010 2009 2008 2007 Other

All Journal Article (19 results) Presentation (9 results) Book (1 results)

  • [Journal Article] E2A and CBP/p300 act in synergy topromote chromatin accessibility of the immunoglobulin κ locus2012

    • Author(s)
      Sakamoto, S., Wakae, K., Anzai, Y., Murai, K., Tamaki, N., Miyazaki, M., Myyazaki, K.,Romanow, W.J., Ikawa, T., Kitamura, D.,Yanagihira, I., Minato, N., Murre, C., and Agata, Y
    • Journal Title

      J. Immunol

      Volume: 188(11) Pages: 5547-60

    • DOI

      doi:10.404/jimmunol.1002346

  • [Journal Article] Increased c-Myc activity and DNA damage inhematopoietic progenitors precede myeloproliferative disease in Spa-1-deficiency2011

    • Author(s)
      Tanaka, H., Tamura, A., Hattori, M., Sekai,M., Hamazaki, Y., and Minato, N
    • Journal Title

      Cancer Science

      Volume: 102 Pages: 784-791

    • DOI

      doi:10.1111/j.1349-7006.2011.01850.x

  • [Journal Article] Spa-1 (Sipa1) controls the invasion and metastasis of human prostate cancers via Rap signal2011

    • Author(s)
      Shimizu Y, Hamazaki Y, Hattori M, Doi K, Terada Y, Kobayashi T, Toda Y, Yamasak T,Inoue T, Kajita Y, Atsushi M, Kamba T, MikamiY, Kamoto T, Yamada T, Ogawa O, Minato N and Nakamura E
    • Journal Title

      Cancer Science

      Volume: 102 Pages: 828-836

    • DOI

      doi:10.1111/j.1349-7006.2011.01876.x

  • [Journal Article] Claudin-4 isinduced in thymocytes of late CD4/CD8 doublepositive stage by E2A and promotes abT cellreceptor.mediated positive selection2011

    • Author(s)
      Kawai. K. Hamazaki, Y., Fujita, H., Fujita,A., Sato, T., Moriwaki, K., Furuse, M., Fujimoto,T., Agata, Y. and Minato, N
    • Journal Title

      Proc. Nat. Acad. Sci. USA

      Volume: 108(10) Pages: 4075-4080

    • DOI

      Doi:10.1073/pnas.1014178108

  • [Journal Article] Anti-PD-1 antibody reduces CD4+ PD-1+ T cells and relieves the lupus-like nephritis of l NZB/W F1mice2010

    • Author(s)
      Kasagi, S, Kawano, S, Okazaki, T, Honjo, T, Morinobu, A, Hatachi, S, Shimatani, K, Tanaka,Y, Minato, N, and Kumagai, S
    • Journal Title

      J.Immunol

      Volume: 184 Pages: 2337-2347

    • DOI

      doi:10.4049/jimmunol.0901652

  • [Journal Article] Spa-1 (Sipa1) and Rap signaling in leukemia and cancer metastasis2009

    • Author(s)
      Minato, N., and Hattori, M
    • Journal Title

      Cancer Science

      Volume: 100 Pages: 17-23

    • DOI

      doi:10.1007/s11748-008-0294-z

  • [Journal Article] Rap signaling in normallymphocyte development and leukemia genesis2009

    • Author(s)
      Minato, N
    • Journal Title

      Immune Network

      Volume: 9 Pages: 35-40

    • DOI

      doi:10.4110/in.2009.9.2.35

  • [Journal Article] Rap signaling is crucial for the competence ofIL-7 response and the development of B-lineagecells2009

    • Author(s)
      Katayama, Y., Sekai, M., Hattori, M.,Miyoshi, I., Hamazaki, Y, and Minato, N
    • Journal Title

      Blood

      Volume: 114 Pages: 1768-1775

    • DOI

      doi:10.1182/blood-2009-03-213371

  • [Journal Article] Memoryphenotype PD-1+ CD4+ T cells expressing C/EBPa underlie T cell immunodepression in senescence and leukemia2009

    • Author(s)
      Shimatani, K., Nakashima, Y., Hattori, M., Hamazaki, Y., and Minato, N
    • Journal Title

      Proc. Nat. Acad. Sci. USA

      Volume: 106 Pages: 15807-15812

    • DOI

      doi:10.1073/pnas.0908805106

  • [Journal Article] Development ofNotch-dependent T cell leukemia by deregulated Rap1 signaling2008

    • Author(s)
      Wang, S-F, Aoki, M., Shinozuka, Y.,Nakashima, Y., Tanaka, H., Taniwaki, F., Hattori,M., and Minato, N
    • Journal Title

      Blood

      Volume: 111 Pages: 3011-3016

    • DOI

      doi:10.1182/blood-2007-07-103119

  • [Journal Article] Structureof the human programmed death (PD)-1 ligand and its complex with PD-1 that inhibits immune responses2008

    • Author(s)
      Lin, D. Y., Tanaka, Y., Iwasaki, M., Gitttis, A. G., Su, H-P., Mikami, B., Okazaki, T., Honjo, T.,Minato, N., and Garboczi, D, N
    • Journal Title

      Proc. Natl. Acad. Sci. USA

      Volume: 105 Pages: 3011-3016

    • DOI

      doi:10.1073/pnas.0712278105

  • [Journal Article] Essential role of Rapsignal in pre-TCR mediated b-selection in ab Tcell development2008

    • Author(s)
      Kometani, K, Moriyama, M, Nakashima, Y,Katayama, Y, Wang, S-F, Saito, T, Hattori, Mand Minato, N
    • Journal Title

      Blood

      Volume: 112 Pages: 4565-4573

    • DOI

      doi:10.1182/blood-2008-06-164517

  • [Journal Article] Medullary thymic epithelial cells expressing Airerepresent a unique lineage derived from claudin-expressing cells2007

    • Author(s)
      Hamazaki, Y, Fujita, H, Kobayashi, T, Choi, Y, H. Scott, Matsumoto, M, and Minato, N
    • Journal Title

      Nature Immunol

      Volume: 8 Pages: 304-311

    • DOI

      PMID:17277780

  • [Journal Article] Regulation of immune responses andhematopoiesis by the Rap1 signal2007

    • Author(s)
      Minato, N, K.Kometani, and M.Hattori
    • Journal Title

      Adv. Immunol

      Volume: 93 Pages: 229-264

    • DOI

      PMID:17383543

  • [Journal Article] Intestinal tumorsinactivated in TGF-b signaling secrete CCL9 andrecruit CCR1+ myeloid cells that help invasion2007

    • Author(s)
      Kitamura, T., Kometani, K., Hashiba, H., Matsunaga, A., Miyoshi. H., Hosogi, H., Aoki, M.,Oshima, M., Hattori, M., Takabayashi, A., Minato,N., and Taketo, M
    • Journal Title

      Nature Gen

      Volume: 39 Pages: 467-475

    • DOI

      PMID:17369830

  • [Journal Article] PD-L1 and tumor-infiltrating CD8+ T lymphocytes are independent prognostic factors of human ovarian cancer2007

    • Author(s)
      Hamanishi J., Mandai, M., Iwasaki, M., Okazaki. T., Tanaka, Y., Yamaguchi, K., Higuchi, T., Yagi, H., Takakura, K, Minato, N., Honjo, T., and Fujii, S
    • Journal Title

      Proc. Natl. Acad. Sci. USA

      Volume: 104 Pages: 3360-3365

    • DOI

      PMID:17360651

  • [Journal Article] Impaired T lymphocyte trafficking in micedeficient in an actin-nucleating protein mDial2007

    • Author(s)
      Sakata D, Taniguchi H, Yasuda S,Adachi-Morishima A, Hamazaki Y, Nakayama R, Miki T, Minato N, and Narumiya S
    • Journal Title

      J. Exp. Med

      Volume: 204 Pages: 2031-2038

    • DOI

      PMID:17682067

  • [Journal Article] T cell lineage determination precedes the initiation of TCRb gene rearrangement2007

    • Author(s)
      Masuda, K, Kakugawa, K, Nakayama, T, Minato, N, Katsura, Y, and Kawamoto, H
    • Journal Title

      J. Immunol

      Volume: 179 Pages: 3699-3706

    • DOI

      PMID:17785806

  • [Journal Article] Role of Rap signal in normal and disordered hematopoiesis

    • Author(s)
      Minato, N
    • Journal Title

      Exp.Cell. Res

      Volume: (Epub ahead of print)

    • DOI

      doi:pii: S0014-4827(13)00168-7.10.1016/j.yexcr.2013.04.009

  • [Presentation] Rap signaling in normal hematoiesisand hematologic malignancy2012

    • Author(s)
      Minato, N
    • Organizer
      IFOM-Kyoto Symposium
    • Place of Presentation
      Milan
    • Year and Date
      2012-10-25
  • [Presentation] Rap G protein: Biology and roles inmalignancy2012

    • Author(s)
      Minato, N
    • Organizer
      Invited Lecture Series
    • Place of Presentation
      Stockholm
    • Year and Date
      2012-05-15
  • [Presentation] Senescence-related T cells; Role insystemic autoimmunity and malignancy2012

    • Author(s)
      Minato, N
    • Organizer
      International Conference on Autoimmunity
    • Place of Presentation
      Tokyo
    • Year and Date
      2012-04-17
  • [Presentation] The impact of leukemia on immunesystem2011

    • Author(s)
      Minato, N
    • Organizer
      International Symposium ofJapanese Hematology Society
    • Place of Presentation
      Yokohama
    • Year and Date
      2011-10-14
  • [Presentation] Immunity and malignancy2011

    • Author(s)
      Minato, N
    • Organizer
      Forum Science in Japan
    • Place of Presentation
      Washington DC
    • Year and Date
      2011-06-20
  • [Presentation] Lymphoid stree-surveillanceresponse2010

    • Author(s)
      Minato, N
    • Organizer
      International Workshop on Cancer Biology
    • Place of Presentation
      Kanazawa
    • Year and Date
      2010-08-28
  • [Presentation] gd-T cells and cancerimmunotherapy2009

    • Author(s)
      Minato, N
    • Organizer
      International Symposium of Japanese Immunology Society
    • Place of Presentation
      Kobe
    • Year and Date
      2009-12-04
  • [Presentation] Rap GTPase in normal lymphohematopoiesis and leukemia2009

    • Author(s)
      Minato, N
    • Organizer
      Invited Lecture Series
    • Place of Presentation
      China
    • Year and Date
      2009-11-02
  • [Presentation] Memory phenotype PD-1 CD4 Tcells expressing C/EBPs underlies the global Tcell immunodepression in senescence andmalignancy2009

    • Author(s)
      Minato, N
    • Organizer
      International KTCC Worshop
    • Place of Presentation
      Kyoto
    • Year and Date
      2009-06-01
  • [Book] Rap1 and Spa-1, "Encyclopedia of Cancer" the second edition2008

    • Author(s)
      Minato, N
    • Total Pages
      2540-2544
    • Publisher
      Springer Press

URL: 

Published: 2014-08-29  

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