effect of vasopressin on lidocaine distribution, anesthetic effect and circulatory dynamics

2018 Fiscal Year Final Research Report

• Project/Area Number: 16K11768
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Surgical dentistry
• Research Institution: The Nippon Dental University
• Principal Investigator: SUNADA KATSUHISA 日本歯科大学, 生命歯学部, 教授 (50171286)
• Project Period (FY): 2016-04-01 – 2019-03-31
• Keywords: バソプレシン / リドカイン / 歯科用局所麻酔薬 / 麻酔効果 / 循環動態

Outline of Final Research Achievements

In this study, we aimed to investigate the anesthetic effect of vasopressin-added local anesthetics. Vasopressin was added to lidocaine, a local anesthetic, and it was administered into the oral cavity of rats to determine its effect on anesthetic effect and cardiovascular changes. Furthermore, the tissue distribution of the lidocaine was also examined using radioactive isotopes. As a result, local administration to oral cavity of 0.03 U / ml vasopressin-added lidocaine reduced tissue blood flow. In addition, it became clear that the anesthetic action was enhanced, duration of tissue localization was prolonged, and hemodynamics was not affected. Therefore, it was thought that vasopressin could be became a useful local anesthetic additive instead of adrenaline.

Free Research Field

歯科麻酔学

Academic Significance and Societal Importance of the Research Achievements

歯科では、十分な効果を得るためにアドレナリンを含んだ局所麻酔薬が頻用されている。一方、高齢化社会の到来に伴って、循環器疾患患者が治療を受ける機会が激増している。これらの患者に対するアドレナリン含有麻酔薬の投与は、血圧上昇や不整脈の原因となる。そこで、循環器に対する影響が小さいバソプレシンの有効性について検討した。その結果バソプレシンは、アドレナリンに代わる有用な局所麻酔添加薬になり得る可能性が示唆された。