2023 Fiscal Year Final Research Report
Drug resistance mechanisms and pathogenic changes in the pathogenic fungus Aspergillus due to exposure to infectious agents.
| Project/Area Number |
18K06668
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
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| Research Institution | Kagawa Nutrition University (2020-2023)
Tokyo University of Pharmacy and Life Science (2018-2019) |
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Principal Investigator |
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| Project Period (FY) |
2018-04-01 – 2024-03-31
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| Keywords | 真菌症 / 薬剤感受性 / 真菌細胞壁 / グルカン |
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| Outline of Final Research Achievements |
Deep mycosis often occurs in easily infected patients, such as cancer patients, and combined infections are not uncommon. Therefore, antiviral and antifungal agents may be administered simultaneously. In this study, we investigated the growth and antifungal susceptibility of cultured Aspergillus strains treated with antivirals.
Aspergillus was cultured in the presence of antivirals in C-limiting medium, and growth of Aspergillus was accelerated in the presence of antivirals. The amount of β-1,3-glucan in the culture supernatant was also increased, and the susceptibility of Aspergillus to antifungal drugs in the presence of antivirals was examined.
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| Free Research Field |
生体防御学
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| Academic Significance and Societal Importance of the Research Achievements |
高度医療が進むにつれて，感染症も複雑化してきている．耐性菌が問題になる中，抗微生物薬の適正使用が叫ばれている．生体内における複数の医薬品同士の相互作用は臨床において非常に重要な問題である. 本研究を通じて，抗微生物薬（感染症薬）の薬物間相互作用に可能性があることが示唆された．今後も臨床現場においては，医薬品のより適切な使用を目指し，このような視点を持ち続けることが必要であると考えられた．
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