2012 Fiscal Year Final Research Report
Molecular mechanism for neuronal diversity and organization in the brain
| Project/Area Number |
19100006
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| Research Category |
Grant-in-Aid for Scientific Research (S)
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| Allocation Type | Single-year Grants |
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| Research Field |
Neuroscience in general
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| Research Institution | Osaka University |
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Principal Investigator |
YAGI Takeshi 大阪大学, 生命機能研究科, 教授 (10241241)
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| Project Period (FY) |
2007 – 2012
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| Keywords | カドヘリン / 神経回路 / 遺伝子制御 |
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| Research Abstract |
To examine molecular mechanism for generating neuronal diversity and for building neural network formation in the brain, we focused to diverse CNR/protocadherin molecules which express in the brain. In this study, we identified the several cis-elements, and revealed that DNA methylation and CTCF are essential to regulate expression of CNR/protocadherin genes in each neuron. And also we demonstrated that CNR/protocadherin- α molecules are essential to correct neural networkformation in the brain.
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Research Products
(23 results)
