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2012 Fiscal Year Final Research Report

Molecular mechanism for neuronal diversity and organization in the brain

Research Project

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Project/Area Number 19100006
Research Category

Grant-in-Aid for Scientific Research (S)

Allocation TypeSingle-year Grants
Research Field Neuroscience in general
Research InstitutionOsaka University

Principal Investigator

YAGI Takeshi  大阪大学, 生命機能研究科, 教授 (10241241)

Project Period (FY) 2007 – 2012
Keywordsカドヘリン / 神経回路 / 遺伝子制御
Research Abstract

To examine molecular mechanism for generating neuronal diversity and for building neural network formation in the brain, we focused to diverse CNR/protocadherin molecules which express in the brain. In this study, we identified the several cis-elements, and revealed that DNA methylation and CTCF are essential to regulate expression of CNR/protocadherin genes in each neuron. And also we demonstrated that CNR/protocadherin- α molecules are essential to correct neural networkformation in the brain.

  • Research Products

    (23 results)

All 2012 2011 2010 2009 2008 2007 Other

All Journal Article (17 results) (of which Peer Reviewed: 17 results) Presentation (2 results) Remarks (1 results) Patent(Industrial Property Rights) (3 results)

  • [Journal Article] Constitutively expressed Protocadherin-a regulates the coalescence and elimination of homotypic olfactory axons through its cytoplasmic region.2012

    • Author(s)
      Hasegawa S, Yagi T.
    • Journal Title

      Front. Mol. Neurosci

      Volume: 5 Pages: 97

    • DOI

      doi:10.3389/fnmol.2012.00097

    • Peer Reviewed
  • [Journal Article] Single-neuron diversity generated by Protocadherin-β cluster in mouse central and peripheral nervous systems.2012

    • Author(s)
      Hirano K, Yagi T.
    • Journal Title

      Front. Mol. Neurosci.

      Volume: 5 Pages: 90

    • Peer Reviewed
  • [Journal Article] CTCF is required for neural development and stochastic expression of clustered Pcdhgenes in neurons.2012

    • Author(s)
      Hirayama T, Yagi T.
    • Journal Title

      Cell Reports

      Volume: 2 Pages: 345-357

    • DOI

      doi:10.1016/j.celrep.2012.06.014.

    • Peer Reviewed
  • [Journal Article] Molecular codes for neuronal individuality and cell assembly in the brain.2012

    • Author(s)
      Yagi T
    • Journal Title

      Front. Mol. Neurosci

      Volume: 5 Pages: 45

    • Peer Reviewed
  • [Journal Article] Restoration of contralateral representation in the mouse somatosensory cortex after crossing nerve transfer2012

    • Author(s)
      Yamashita H, Yagi T
    • Journal Title

      PLoS ONE

      Volume: 7 Pages: e35676

    • Peer Reviewed
  • [Journal Article] Identification of the cluster control region for the protocadherin-b genes located beyond the protocadherin-g cluster.2011

    • Author(s)
      Yokota S, Yagi T
    • Journal Title

      J. Biol. Chem.

      Volume: 284 Pages: 32002-32014

    • Peer Reviewed
  • [Journal Article] A Novel Instrumented Multi-Peg Running Wheel System, Step-Wheel, for Monitoring and Controlling Complex Sequential Stepping in Mice.2010

    • Author(s)
      Kitsukawa T, Yagi T
    • Journal Title

      J. Neurophysiol.

      Volume: 106 Pages: 479-487

    • Peer Reviewed
  • [Journal Article] Total expression and dual gene-regulatory mechanisms maintained in deletions and duplications of the Pcdha cluster2009

    • Author(s)
      Noguchi Y, Yagi T
    • Journal Title

      J. Biol. Chem.

      Volume: 284 Pages: 32002-32014

    • Peer Reviewed
  • [Journal Article] Protocadherin-alpha family is required for serotonergic projections to appropriately innervate target brain areas2009

    • Author(s)
      Katori S, Yagi T
    • Journal Title

      J. Neurosci.

      Volume: 29 Pages: 9137-9147

    • Peer Reviewed
  • [Journal Article] DNA polymerase delta is required for early mammalian embryogenesis.2009

    • Author(s)
      Uchimura A, Yagi T
    • Journal Title

      PLoS ONE

      Volume: 4 (1) Pages: e4184

    • Peer Reviewed
  • [Journal Article] Expression levels of Protocadherin-alpha transcripts are decreased by nonsense-mediated mRNA decay with frameshift mutations and by high DNA methylation in their promoter regions2009

    • Author(s)
      Kaneko R, Yagi T
    • Journal Title

      Gene

      Volume: 430 Pages: 86-94

    • Peer Reviewed
  • [Journal Article] Clustered protocadherin family2008

    • Author(s)
      Yagi T
    • Journal Title

      Dev. Growth. Differ.

      Volume: 50 Pages: S131-S140

    • Peer Reviewed
  • [Journal Article] The protocadherin-alpha family is involved in axonal coalescence of olfactory sensory neurons into glomeruli of the olfactory bulb in mouse2008

    • Author(s)
      Hasegawa S, Yagi T
    • Journal Title

      Mol. Cell. Neurosci

      Volume: 38 Pages: 66-79

    • Peer Reviewed
  • [Journal Article] Down-regulation of protocadherin-alpha A isoforms in mice changes contextual fear conditioning and spatial working memory.2008

    • Author(s)
      Fukuda E, Yagi T
    • Journal Title

      Eur. J. Neurosci

      Volume: 28 Pages: 1362-1376

    • Peer Reviewed
  • [Journal Article] Relationship between DNA methylation states and transcription of individual isoforms encoded by the protocadherin-alpha gene cluster.2008

    • Author(s)
      Kawaguchi M, Yagi T
    • Journal Title

      J. Biol. Chem

      Volume: 283 Pages: 12064-12075

    • Peer Reviewed
  • [Journal Article] Protocadherin family: diversity, structure, and function.2007

    • Author(s)
      Morishita H & Yagi T
    • Journal Title

      Curr. Opin. Cell. Biol.

      Volume: 19 Pages: 584-592

    • Peer Reviewed
  • [Journal Article] Interactions between Plexin-A2, Plexin-A4, and Semaphorin 6A Control Lamina-Restricted Projection of Hippocampal Mossy Fibers.2007

    • Author(s)
      Suto F, Yagi T
    • Journal Title

      Neuron

      Volume: 53 Pages: 535-547

    • Peer Reviewed
  • [Presentation] Neuronal diversity by clustered protocadherin genes.2012

    • Author(s)
      Yagi T
    • Organizer
      India-Japan Developmental Workshop
    • Place of Presentation
      Bangalor India
    • Year and Date
      2012-01-09
  • [Presentation] Genetic codes for generating the complex brain. Neuronal diversity by clustered protocadherin genes2010

    • Author(s)
      Yagi T
    • Organizer
      Tohoku University-Taiwan Neuroscience Workshop
    • Place of Presentation
      Keynote Speech. Taipei Taiwan
    • Year and Date
      2010-01-22
  • [Remarks] ホームページ

    • URL

      http://www.fbs.osaka-u.ac.jp/labs/yagi/index.htm

  • [Patent(Industrial Property Rights)] 特徴抽出装置、特徴抽出方法、及び、そのプログラム2010

    • Inventor(s)
      木津川尚史、八木 健
    • Industrial Property Rights Holder
      大阪大学
    • Industrial Property Number
      特願 2010-234064
    • Filing Date
      2010-10-18
  • [Patent(Industrial Property Rights)] 水溶性近赤外蛍光材料およびマルチモーダル水溶性近赤外蛍光材料2008

    • Inventor(s)
      神隆、吉岡芳親、駒井豊、大澤五住、八木健、金子凉輔、精山明敏、関 淳二
    • Industrial Property Rights Holder
      大阪大学
    • Industrial Property Number
      特願 2008-130884 号
    • Filing Date
      2008-05-19
  • [Patent(Industrial Property Rights)] さえずり変異マウス2008

    • Inventor(s)
      八木 健、内村有邦、日高裕子、古澤 満
    • Industrial Property Rights Holder
      大阪大学
    • Industrial Property Number
      特願 2008-052705
    • Filing Date
      2008-03-03

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Published: 2014-08-29  

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