2010 Fiscal Year Final Research Report
A novel strategy of prevention of gastric cancer recurrence-prediction of effect of chemotherapy for potential recurrence after curative operation-
| Project/Area Number |
19591569
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Kanazawa Medical University |
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Principal Investigator |
KOSAKA Takeo Kanazawa Medical University, 医学部, 教授 (30186663)
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| Project Period (FY) |
2007 – 2010
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| Keywords | 胃癌 / 化学療法 / 予後因子 / 5-FU代謝酵素 |
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| Research Abstract |
Multivariate analysis identified positive lymph node metastasis, low total cholesterol level, a small number of lymphocytes, positive venous invasion, and elevated serum CA19-9 level as independent prognostic factors in curatively resected gastric cancer patients. It should be considered to administer anti-cancer drugs in such cases. In addition, it may be useful to evaluate enzyme activity regarding 5-FU metabolism in predicting the effect of anticancer drugs and prognosis of gastric cancer patient.
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