2019 Fiscal Year Final Research Report
Spatio-temporal control of cell-cell interactions during collective migration of neural crest cells
Project/Area Number |
19K23830
|
Research Category |
Grant-in-Aid for Research Activity Start-up
|
Allocation Type | Multi-year Fund |
Review Section |
0802:Biomedical structure and function and related fields
|
Research Institution | University of Miyazaki |
Principal Investigator |
|
Project Period (FY) |
2019-08-30 – 2020-03-31
|
Keywords | アクチン / 細胞運動 |
Outline of Final Research Achievements |
In the process of forming the body of multicellular organisms, the force generated by each cell is transmitted to adjacent cells by a device called "cell-cell adhesion", thereby forming the shape of the entire tissue. It has recently become evident that such transmission of force between cells is controlled by dynamically changing the formation of actomyosin at the cell-cell adhesion site. In this study, we focused on the formin protein Fhod3, which regulates the formation of actomyosin, and clarified its potential involvement in the morphological changes of neuroepithelial cells and migration of neural crest cells.
|
Free Research Field |
分子細胞薬理学
|
Academic Significance and Societal Importance of the Research Achievements |
本研究を通じて細胞間の力の伝達機構を明らかにすることは、多細胞生物の細胞間コミュニケーションの理解に新たな視点をもたらすことが期待される。また、本研究の成果は、細胞間コミュニケーションの破綻に基づく各種ヒト疾患の病態理解に通じると同時に、その機構を標的とした創薬は、がん、免疫、創傷治癒、遺伝性疾患といった幅広い領域に貢献することが期待される。
|