2020 Fiscal Year Final Research Report
Analysis of the pain mechanisms in the spinal cord involved in receptors of hypothalamic hormones and calcium channels
Project/Area Number |
19K23836
|
Research Category |
Grant-in-Aid for Research Activity Start-up
|
Allocation Type | Multi-year Fund |
Review Section |
0802:Biomedical structure and function and related fields
|
Research Institution | University of Occupational and Environmental Health, Japan |
Principal Investigator |
|
Project Period (FY) |
2019-08-30 – 2021-03-31
|
Keywords | 神経障害性疼痛 / 神経障害 / 脊髄 / 興奮性ニューロン / 抑制性ニューロン / 介在ニューロン |
Outline of Final Research Achievements |
The spinal cord contains many different types of neurons and they are involved in pain modulation. In the present study, it is confirmed that the expression of the calcium channel α2δ1 subunit was up-regulated, that neuronal activity of excitatory neurons was up-regulated, and that the number and neuronal activity of inhibitory neurons was not affected in the dorsal spinal cord of partial sciatic nerve ligation rats. These results suggest that excitatory neurons in the dorsal spinal cord are predominantly involved in neuropathic pain.
|
Free Research Field |
神経科学
|
Academic Significance and Societal Importance of the Research Achievements |
神経障害性疼痛は治療に難渋することが多く、その発生機序を解明することは重要な医学的および学術的な課題である。本研究では、神経障害性疼痛の発生に脊髄後角抑制性ニューロンの機能低下ではなく、脊髄後角興奮性ニューロンの機能亢進が関与することを示唆する結果が得られた。以上より、神経障害性疼痛の発生機序の解明に寄与する社会的意義のある研究成果が得られた。
|