2011 Fiscal Year Final Research Report
Functional and morphological integrated assessments of hepato-biliary-pancreatic carcinomas using 320 detector-row CT
| Project/Area Number |
21591563
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Kobe University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
OHNO Yoshiharu 神戸大学, 医学研究科, 特命准教授 (30324924)
TAKENAKA Daisuke 神戸大学, 医学研究科, 准教授 (60258233)
MAEDA Tetsuo 神戸大学, 医学研究科, 特命講師 (00457095)
MATSUMOTO Sumiaki 神戸大学, 医学研究科, 特命講師 (60397833)
SUGIMURA Kazuro 神戸大学, 医学研究科, 教授 (00136384)
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| Co-Investigator(Renkei-kenkyūsha) |
MURASE Kenya 大阪大学, 医学研究科, 教授 (50157773)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 領域検出器型CT / 上腹部 / 臓器血流・機能測定 / 臓器血流測定ソフトウエア / 低X線量CT撮影 / 形態・機能融合診断法 |
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| Research Abstract |
We evaluated newly-developed Area-Detector CT in functional and morphological assessments of the upper abdominal organ function and diseases. Area-Detector CT was superior to conventional CT in assessment of fine abdominal vessels. We developed CT scanning protocol and injection protocol of contrast medium for abdominal functional(perfusion) CT, correction software for respiratory misregistrations, and software for perfusion analysis with three different analytic methods. Our results showed irradiation during perfusion CT can be reduced to 1/3 and volume and injection rate of contrast medium can be reduced to 1/3 of those in the conventional methods and respiratory misregistrations less than 3 cm can be satisfactorily corrected. Effects of cardiac function were found and it needs to be compensated. In patients with abdominal diseases, we found new findings such as interactions in blood perfusion among the organs and useful perfusion parameters for diagnosis for malignant tumors. It was also found that perfusion CT is useful for assessment of tumor responses after radiotherapy and anticancer agents as well as residual organ function. The results of this study suggest functional and morphological integrated CT using Area-Detector CT can be superior to those of conventional morphological CT in assessments of the upper abdominal organ function and diseases.
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Research Products
(35 results)
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[Journal Article] Capability of abdominal 320-detector row CT for small vasculature assessment compared with that of 64-detector row CT2011
Author(s)
Kitajima K, Maeda T, Ohno Y, Yoshikawa T, Konishi M, Kanda T, Onishi Y, Matsumoto K, Koyama H, Takenaka D, Sugimura K
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Journal Title
Eur J Radiol
Volume: 80(2)
Pages: 219-23
Peer Reviewed
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[Journal Article] Comparison of Capability of Abdominal 320-Detector Row CT and of 16-Detector Row CT for Small Vasculature Assessment2011
Author(s)
Sugihara R, Kitajima K, Maeda T, Yoshikawa T, Konishi M, Kanata N, Kanda T, Koyama H, Takenaka D, Ohno Y, Sugimura K
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Journal Title
Kobe J Med Sci
Volume: 56(4)
Pages: E154-61
Peer Reviewed
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[Journal Article] Differentiation of malignant and benign pulmonary nodules with quantitative first-pass 320-detector row perfusion CT versus FDG PET/CT2011
Author(s)
Ohno Y, Koyama H, Matsumoto K, Onishi Y, Takenaka D, Fujisawa Y, Yoshikawa T, Konishi M, Maniwa Y, Nishimura Y, Ito T, Sugimura K
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Journal Title
Radiology
Volume: 258(2)
Pages: 599-609
Peer Reviewed
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[Journal Article] Hepatic CT perfusion measurements : A feasibility study for radiation dose reduction using new image reconstruction method
Author(s)
Negi N, Yoshikawa T, Ohno Y, Somiya Y, Sekitani T, Sugihara N, Koyama H, Kanda T, Kanata N, Murakami T, Kawamitsu H, Sugimura K
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Journal Title
Eur J Radiol
Volume: (in press)
DOI
Peer Reviewed
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[Journal Article] Perfusion measurement of the whole upper abdomen of patients with and without liver diseases : Initial experience with 320-detector row CT
Author(s)
Kanda T, Yoshikawa T, Ohno Y, Fujisawa Y, Kanata N, Yamaguchi M, Seo Y, Yano Y, Koyama H, Kitajima K, Takenaka D, Sugimura K
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Journal Title
Eur J Radiol
Volume: (in press)
DOI
Peer Reviewed
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[Journal Article] Reduced-dose chest CT with 3D automatic exposure control vs. standard chest CT : Quantitative assessment of emphysematous changes in smokers' lung parenchyma
Author(s)
Koyama H, Ohno Y, Yamazaki Y, Matsumoto K, Onishi Y, Takenaka D, Yoshikawa T, Nishio M, Matsumoto S, Murase K, Nishimura Y, Sugimura K
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Journal Title
Eur J Radiol
Volume: (in press)
DOI
Peer Reviewed
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[Presentation] Whole Upper Abdominal CT Perfusion Measurements : Effects of Contrast Medium Iodine Concentration on the Values Estimated by Three Analytic Methods2011
Author(s)
Kanda T, Yoshikawa T, Ohno Y, Fujisawa Y, Murakami T, Koyama S, Kanata N, Takenaka D, Koyama H, Kitajima K, Sugimura K
Organizer
97th Annual Meeting of Radiological Society of North America
Place of Presentation
Chicago
Year and Date
2011-11-28
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[Presentation] Whole Upper Abdominal CT Perfusion Measurements : Optimization of Contrast Medium Administration with 320-Detector Row CT2010
Author(s)
Kanata N, Yoshikawa T, Konishi M, Ohno Y, Kanda T, Koyama H, Takenaka D, Onishi Y, Kitajima K, Koto N, Sugimura K
Organizer
96th Annual Meeting of Radiological Society of North America
Place of Presentation
Chicago
Year and Date
2010-11-29
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