2010 Fiscal Year Final Research Report
Expression analysis of endogenous retroviral elements in canine malignant tumors.
| Project/Area Number |
21780288
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Clinical veterinary science
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| Research Institution | Yamaguchi University |
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Principal Investigator |
BABA Kenji Yamaguchi University, 農学部, 助教 (90452367)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 内在性レトロウイルス / 悪性腫瘍 / 犬 |
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| Research Abstract |
An endogenous retroviral envelope gene was newly identified in canine genome. The predicted amino acid sequence indicated that the retroviral element belonged to the genus Betaretrovirus and encoded a functional envelope protein. The expression of the envelope mRNA was shown in canine malignant melanoma cell lines. This study indicated that the newly identified retroviral envelope may be a tumor antigen in canine malignant melanoma.
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