2010 Fiscal Year Final Research Report
Analysis of silencing mechanism of INK4A gene expression during tumorigenesis with in vivo imaging system
| Project/Area Number |
21790332
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Pathological medical chemistry
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| Research Institution | Japanese Foundation For Cancer Research |
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Principal Investigator |
YAMAKOSHI Kimi Japanese Foundation For Cancer Research, 癌研究所がん生物部, 研究員 (50423398)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 分子腫瘍学 |
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| Research Abstract |
To elucidate molecular mechanisms of p16^<INK4a> gene silencing during tumorigenesis, we used bioluminescence imaging for non-invasive and real-time analysis of p16^<INK4a> expression under various physiological conditions in living mice. As a result, we discovered that oncogenic insults, such as Ras activation, provoke epigenetic de-repression of p16^<INK4a> expression through reduction of DNMT1 level as a DNA damage response in vivo.
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Research Products
(7 results)
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[Journal Article] Intrinsic cooperation between p16^<INK4a> and p21^<Waf1/Cip1> in the onset of cellular senescence and tumor suppression in vivo.2010
Author(s)
Takeuchi, S., Takahashi, A., Motoi, N., Yoshimoto, S., Tajima, T., Yamakoshi, K., Hirao, A., Yanagi, S., Fukami, K., Ishikawa, Y., Sone, S., Hara, E., Ohtani, N.
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Journal Title
Cancer Res. 15,70(22)
Pages: 9381-9390
Peer Reviewed
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[Journal Article] Real-time in vivo imaging of p16^<INK4a> reveals cross talk with p53.2009
Author(s)
Yamakoshi, K., Takahashi, A., Hirota, F., Nakayama, R., Ishimaru, N., Kubo, Y., Mann, DJ., Ohmura, M., Hirao, A., Saya, H., Arase, S., Hayashi, Y., Nakao, K., Matsumoto, M., Ohtani, N., Hara, E.
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Journal Title
J.Cell Biol. 10,186(3)
Pages: 393-407
Peer Reviewed
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