The mechanism of cell death of macrophages by Nocardia infection

2010 Fiscal Year Final Research Report

• Project/Area Number: 21790791
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Respiratory organ internal medicine
• Research Institution: Showa University (2010); National Institute of Infectious Diseases (2009)
• Principal Investigator: ISHINO Keiko Showa University, 薬学部, 准教授 (50332359)
• Project Period (FY): 2009 – 2010
• Keywords: 細菌感染 / マクロファージ / 細胞死 / 遺伝子発現

Research Abstract

To investigate the molecular mechanism of the cell death in macrophage cells by Nocardia infection, we examined the gene expression of host cells by the microaaray system when wild-type or cytotoxicity-negative mutant strain infected macrophage cells. We showed that some cell adhesion molecules related to the cell death of macrophages by Nocardia infection.

Research Products

• [Journal Article] Identification of nocobactin NA biosynthetic gene clusters in Nocardia farcinica. (2011)
  • Author(s): Hoshino Y, Chiba K, Ishino K, Fukai T, Igarashi Y, Yazawa K, Mikami Y, Ishikawa J.
  • Journal Title: J Bacteriol. 93 Pages: 441-448
  • Peer Reviewed
• [Presentation] 病原性放線菌ノカルジアltsA遺伝子産物の機能解析 (2011)
  • Author(s): 石野敬子、渋谷健太、星野泰隆、石川淳
  • Organizer: 日本薬学会第131年会
  • Place of Presentation: 静岡
  • Year and Date: 20110328-20110331
• [Presentation] ltsA遺伝子のノカルジアの病原性への関与 (2010)
  • Author(s): 石野敬子、渋谷健太、星野泰隆、石川淳
  • Organizer: 第83回日本細菌学会総会
  • Place of Presentation: 横浜
  • Year and Date: 20100327-20100329
• [Presentation] 病原性放線菌Nocardia farcinicaのアミノグリコシド耐性機構の解明 (2010)
  • Author(s): 藤井匠子、石野敬子、千葉和宏、石川淳
  • Organizer: 第83回日本細菌学会総会
  • Place of Presentation: 横浜
  • Year and Date: 20100327-20100329
• [Presentation] 病原性放線菌ノカルジア病原性へのノコバクチンの関与 (2009)
  • Author(s): 石野敬子、星野泰隆、千葉和宏、平井明香、石川淳
  • Organizer: 第29回日本細菌学会関東支部総会
  • Place of Presentation: 東京
  • Year and Date: 20091105-20091106
• [Presentation] Nocobactin production is required for virulence of Nocardia farcinica (2009)
  • Author(s): Ishino, K., Hoshino, Y., Chiba, K., Hirai, A., Ishikawa, J.
  • Organizer: 15th International Symposium on the Biology of Actinomycetes.
  • Place of Presentation: Shanghai, China.
  • Year and Date: 20090800
• [Remarks] Nocardia farcinica Genome Project Page : ホームページ等
  • URL: http://nocardia.nih.go.jp/