2011 Fiscal Year Final Research Report
Role of Wnt/β-catenin signaling on cartilage matrix degradation
Project/Area Number |
21791417
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Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Single-year Grants |
Research Field |
Orthopaedic surgery
|
Research Institution | Juntendo University |
Principal Investigator |
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Project Period (FY) |
2009 – 2011
|
Keywords | 軟骨基質分解 / 変形性関節症 |
Research Abstract |
We created a new transgenic mouse model in which Wnt/β-catenin signaling can be activated in cartilage for specific periods of time. Our data provide evidence that Wnt/β-catenin signaling has important and distinct roles in growth plate and articular cartilage and that postnatal dysregulation of this signaling pathway causes diverse structural and functional changes in the two cartilaginous structures.
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Research Products
(7 results)