2012 Fiscal Year Final Research Report
Creation of artificial clock proteins to induce rhythmic gene expression
| Project/Area Number |
22710213
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Living organism molecular science
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| Research Institution | Kyoto University |
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Principal Investigator |
IMANISHI Miki 京都大学, 化学研究所, 助教 (80362391)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 遺伝子発現 / ジンクフィンガー / 人工転写因子 |
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| Research Abstract |
An artificial zinc finger transcription factor targeting a core clock gene was designed and it successfully changed the circadian time. A simple system to manipulate gene expression patterns to be circadian was also constructed using a zinc finger motif. These artificial proteins would be useful for elucidating the mechanism of rhythmic gene expression and for manipulating gene expression.
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