2016 Fiscal Year Final Research Report
Analysis of growth and differentiation network system for immune cells of adipocyte by hormone during childhood
| Project/Area Number |
24591515
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Oita University (2014-2016)
Kyushu University (2012-2013) |
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Principal Investigator |
Ihara Kenji 大分大学, 医学部, 教授 (80294932)
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| Project Period (FY) |
2012-04-01 – 2017-03-31
|
| Keywords | 成長ホルモン / 脂肪細胞 / 免疫細胞 |
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| Outline of Final Research Achievements |
We studied growth hormone (GH) for the differentiation and proliferation of adipocytes via activation of monocytes. Pretreatment with GH, RAW 264 cells decreased the degree of reduction of adiponectin production when co-cultured with adipocytes. It was presumed that some humoral factors produced by macrophage with GH stimulation had influenced on adiponectin expression from adipocytes. Next, metabolome analysis of the produced factors from RAW 264 cell with or without GH treatment suggested the significant changes in amino acid metabolites (such as glutamine and glutamic acid) in the TCA cycle.
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| Free Research Field |
小児内分泌学
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