KAKEN — Research Projects | Researcher Number: 90257858

Search Results: 13 results / Researcher Number: 90257858

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1. 頭蓋顎顔面修復への応用を目指した、heterogeneticな組織/細胞の動態解明

Research Project

Research Category	Grant-in-Aid for Scientific Research (B)
Review Section	Basic Section 56070:Plastic and reconstructive surgery-related
Research Institution	Tokyo Medical and Dental University
Principal Investigator	井関祥子東京医科歯科大学, 大学院医歯学総合研究科, 教授
Project Period (FY)	2024-04-01 – 2027-03-31Granted
Keywords	頭蓋冠 / 神経堤 / 中胚葉 / 骨修復 / 骨芽細胞
Outline of Research at the Start	これまで、発生過程における由来によらず、例えば骨格系組織である骨や軟骨を構築する細胞の特徴は同じであると考えられてきたが、近年の報告では異なることが示唆されている。マウス頭蓋冠の神経堤由来の前頭骨と中胚葉由来の頭頂骨では、骨修復能が頭頂骨のほうが高いことが示されている。ヒトでも、神経堤由来の鼻軟骨と ...

2. Cellular dynamics in calvarial bone healing

Research Project

Research Category	Grant-in-Aid for Scientific Research (B)
Review Section	Basic Section 56070:Plastic and reconstructive surgery-related
Research Institution	Tokyo Medical and Dental University
Principal Investigator	ISEKI Sachiko 東京医科歯科大学, 大学院医歯学総合研究科, 教授
Project Period (FY)	2021-04-01 – 2024-03-31Completed
Keywords	マウス頭蓋冠 / 膜性骨 / 骨修復 / FGF18 / BMP2 / M2マクロファージ / 骨髄間質細胞 / 頭蓋冠 / 骨欠損 / ナノゲル / 頭蓋冠幹細胞 / マクロファージ / メカノシグナル / 頭蓋冠骨 / ポリロタキサン
Outline of Research at the Start	頭蓋冠骨欠損の修復は困難で、人工骨やバイオマテリアルによる骨修復（骨形成）の促進が試みられている。一方、症候群性の頭蓋縫合早期癒合症では、手術による癒合部の分離後の再癒合が高頻度で起き、骨修復を抑制する方策が望まれる。骨修復において、縫合部に存在する頭蓋冠幹細胞の修復部位への動員、炎症から組織修復過 ...
Outline of Final Research Achievements	The mouse critical-sized calvarial defect healing was stabilized by addition of fibroblast growth factor 18 (FGF18) to bone morphogenetic protein 2 (B ...

Research Products of this project	Int'l Joint Research (3 results) Journal Article (7 results, of which Int'l Joint Research: 2 results, Peer Reviewed: 3 results, Open Access: 2 results) Presentation (8 results, of which Int'l Joint Research: 2 results, Invited: 4 results)

3. Quantification of craniofacial growth by machine learning

Research Project

Research Category	Grant-in-Aid for Challenging Research (Exploratory)
Review Section	Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields
Research Institution	Tokyo Medical and Dental University
Principal Investigator	Sachiko Iseki 東京医科歯科大学, 大学院医歯学総合研究科, 教授
Project Period (FY)	2018-06-29 – 2021-03-31Completed
Keywords	頭蓋 / 成長 / 機械学習 / 定量化 / 頭蓋冠 / 形態 / 頭蓋縫合早期癒合症 / 幾何学的形態解析法 / X線microCT / 骨格形態 / X線μCT画像
Outline of Final Research Achievements	The diagnosis of congenital anomalies on craniofacial region is usually evaluated by doctors subjectively or based on their experience. However, the o ...

Research Products of this project	Int'l Joint Research (1 results) Journal Article (2 results) Presentation (2 results, of which Int'l Joint Research: 1 results)

4. Classification and pathological elucidation of Craniosynostosis by the differentiation's pattern of iPS cells

Research Project

Research Category	Grant-in-Aid for Scientific Research (B)
Research Field	Plastic surgery
Research Institution	Tokyo Medical and Dental University
Principal Investigator	Iseki Sachiko 東京医科歯科大学, 大学院医歯学総合研究科, 教授
Project Period (FY)	2017-04-01 – 2020-03-31Completed
Keywords	頭蓋縫合早期癒合症 / iPS細胞 / 骨芽細胞 / 骨芽細胞分化 / iPS / 遺伝子発現 / 遺伝子発現プロファイル / 遺伝子発現パターン / エピジェネティクス
Outline of Final Research Achievements	We detect predominant difference of osteogenic gene expression between craniosynostosis and non-craniosynostosis. In non-craniosynostosis, results als ...

Research Products of this project	Journal Article (7 results, of which Int'l Joint Research: 4 results, Peer Reviewed: 7 results, Open Access: 1 results) Presentation (7 results, of which Int'l Joint Research: 2 results, Invited: 2 results)

5. Application of biomaterials for regulation of osteoblast differentiation to craniosynostosis

Research Project

Research Category	Grant-in-Aid for Challenging Exploratory Research
Research Field	Plastic surgery
Research Institution	Tokyo Medical and Dental University
Principal Investigator	ISEKI Sachiko 東京医科歯科大学, 大学院医歯学総合研究科, 教授
Project Period (FY)	2016-04-01 – 2018-03-31Completed
Keywords	craniosynostosis / osteoblast / diffferentiation / polyrotaxane / ポリロタキサン / 頭蓋縫合早期癒合症 / 骨芽細胞分化 / 外科 / 生体分子 / 発生分化 / 歯学 / 再生医学
Outline of Final Research Achievements	Craniosynostosis involves the premature bony closure of the cranial sutures, which is due to early and rapid ossification. The current treatment modal ...

Research Products of this project	Journal Article (4 results, of which Int'l Joint Research: 3 results, Peer Reviewed: 4 results, Open Access: 1 results) Presentation (3 results, of which Int'l Joint Research: 1 results, Invited: 1 results)

6. Development of the new cancer radical cure treatmentby the immune cells and the factor which control multiplicative growth and recjection of tumor cells in the skin.

Research Project

Research Category	Grant-in-Aid for Young Scientists (B)
Research Field	Plastic surgery
Research Institution	Osaka Medical College
Principal Investigator	IBATA Minenori 大阪医科大学, 医学部, 非常勤医師
Project Period (FY)	2010 – 2012Completed
Keywords	癌 / 免疫学 / マクロファージ / Meth A 線維肉腫細胞 / INF-γ / 細胞障害性 T リンパ球 / Meth A繊維肉腫細胞 / IFN-γ / 細胞傷害性Tリンパ球 / ワクチン効果 / I-10精巣癌細胞 / Meth A線維肉腫細胞 / 細胞障害性Tリンパ球
Research Abstract	When the tumor cells were intradermally transplanted syngeneic of mice, the tumor cells were spontaneously rejected four sevenths of frequency, and th ...

Research Products of this project	Journal Article (2 results, of which Peer Reviewed: 2 results) Presentation (5 results)

7. Fund a mental research for treatment of keloid and hypertrophic scar

Research Project

Research Category	Grant-in-Aid for Scientific Research (C)
Research Field	Plastic surgery
Research Institution	Osaka Medical College
Principal Investigator	UEDA Koichi Osaka Medical College, Faculty of Medicine, Professor
Project Period (FY)	2004 – 2006Completed
Keywords	keloid / hypertrophic scar / immunohistochemistry / VEGF
Research Abstract	We have previously shown that the adenosine triphosphate (ATP) content of keloids remains high for a long time. In keloids, anaerobic glycolysis may b ...

Research Products of this project	Journal Article (4 results)

8. Mechanism of ischemia-reperfusion injury

Research Project

Research Category	Grant-in-Aid for Scientific Research (C)
Research Field	Plastic surgery
Research Institution	Osaka Medical College
Principal Investigator	UEDA Kouichi Osaka Medical College Faculty of Medicine Associate Professor
Project Period (FY)	2000 – 2002Completed
Keywords	ischemia-reperfusion / macropharge / Dichloromethylene diphosphonate / rat skin flaps
Research Abstract	The purpose of this study is to evaluate whether macropharge is related to ischemia-reperfusion injury. The concern of macropharge was investigated by ...

Research Products of this project	Publications (2 results)

9. The Experimental Study : The Effect and Function of Sulfatide in Flap Transplant

Research Project

Research Category	Grant-in-Aid for Scientific Research (C)
Research Field	Plastic surgery
Research Institution	Osaka Medical College
Principal Investigator	TAJIMA Sadao Faculty of Medicine, Osaka Medical College, Professor
Project Period (FY)	1998 – 1999Completed
Keywords	Sulfatide / Selectin / Adhesion molecule / Flap survival / Flap necrosis / Reperfusion injury / Flap transplantation / Microcirculation
Research Abstract	Sulfatide reacting strongly with L- and P-selection plays an important role in the initiation of neutrophil-endothelial interactions occurring in inju ...

Research Products of this project	Publications (5 results)

10. 同種多弁移植における細胞間接着分子の制御とFTY720による免疫寛容誘導

Research Project

Research Category	Grant-in-Aid for Encouragement of Young Scientists (A)
Research Field	General surgery
Research Institution	Osaka Medical College
Principal Investigator	上田晃一大阪医科大学, 医学部, 講師
Project Period (FY)	1997 – 1998Completed
Keywords	FTY720 / 同種多弁移植 / 接着分子 / 免疫寛容 / 同種皮弁移植 / 免疫抑制剤
Research Abstract	平成9年度はドナーを近交系Fishcerラット、レシピエントを近交系Lewisラットとして、群:同種皮弁移植をおこなった(n=6)。腹部より血管吻合を介して移植された遊離島状皮弁は平均8.17日後に拒絶による壊死に陥った。他家の報告によるラット心臓移植の平均11日、同じくラット肝臓移植の平均9日に ...

11. 抗接着分子抗体を用いた細胞間シグナル伝達阻害による皮弁の再灌流阻害の防止

Research Project

Research Category	Grant-in-Aid for Encouragement of Young Scientists (A)
Research Field	General surgery
Research Institution	Osaka Medical College
Principal Investigator	上田晃一大阪医科大学, 医学部, 講師
Project Period (FY)	1996 – 1997Completed
Keywords	再灌流障害 / モノクロナール抗体 / スルファチド / 皮弁
Research Abstract	1,研究方法

12. 同種皮弁移植における細胞間シグナル伝達分子の抑制による免疫寛容誘導

Research Project

Research Category	Grant-in-Aid for Scientific Research (C)
Research Field	General surgery
Research Institution	Osaka Medical College
Principal Investigator	田嶋定夫大阪医科大学, 医学部, 教授
Project Period (FY)	1996 – 1997Completed
Keywords	同種皮弁移植 / 接着分子 / モノクロナール抗体 / スルファチド / 免疫寛容
Research Abstract	1,実験モデル

13. セレクチンを介した細胞間シグナル阻害による筋皮弁の再灌流障害の防止

Research Project

Research Category	Grant-in-Aid for Encouragement of Young Scientists (A)
Research Field	General surgery
Research Institution	Osaka Medical College
Principal Investigator	上田晃一大阪医科大学, 医学部, 講師
Project Period (FY)	1995Completed
Keywords	再灌流障害 / 接着分子 / セレクチン
Research Abstract	研究目的脈管茎における接着分子のうちセレクチンファミリーは炎症反応に強く関係しており、白血球の血管内皮細胞への強固な接着よりも、その前におこるローリング現象に関与している。セレクチンの阻害剤であるSulfatidesを用い、虚血後再灌流時に生じる一連の白血球の反応を抑制し、白血球を介する再灌流障害 ...