| Project/Area Number |
15K10221
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Cardiovascular surgery
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| Research Institution | Wakayama Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
岡村 吉隆 和歌山県立医科大学, 医学部, 博士研究員 (80245076)
打田 俊司 愛媛大学, 医学部附属病院, 准教授 (10246556)
本田 賢太朗 和歌山県立医科大学, 医学部, 講師 (60508018)
湯崎 充 和歌山県立医科大学, 医学部, 助教 (80405448)
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| Project Period (FY) |
2015-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
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| Keywords | 心不全 / 再生医療 / 幹細胞治療 / 間葉系幹細胞 / HMGB1タンパク / HMGB1 |
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| Outline of Final Research Achievements |
In this study, our aim was that we evaluated whether the transplantation of mesenchymal stem cells overexpressing HMGB1 protein, which played a important role in the cell therapy to heart failure, had a therapeutic effect for heart failure model rats or not. we, however, failed to establish overexpressing HMGB1 protein to mesenchymal stem cells. Therefore, we could not achieve our aim in this study.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究の仮説通りに、HMGB1タンパクを過剰に分泌するように遺伝子操作をした間葉系幹細胞が心不全を起こした心臓に移植されて、心機能の改善等の治療効果があったのならば、現在の心不全に対する幹細胞治療をもっと効果的な標準的な治療法として今後確立させることに役立てると思われる。
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