| Project/Area Number |
15K19020
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|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pathological medical chemistry
|
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
Nagano Yoshiko 東京医科歯科大学, 大学院医歯学総合研究科, 助教 (10723819)
|
|---|
| Project Period (FY) |
2015-04-01 – 2017-03-31
|
| Project Status |
Completed (Fiscal Year 2016)
|
| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | HTLV-1 / ATL / TGF-beta / IL-10 / 免疫抑制 |
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| Outline of Final Research Achievements |
Adult T cell Leukemia (ATL) is caused by infection with Human T cell Leukemia Virus-1 (HTLV-1). HTLV-1-specific immune responses are suppressed in ATL, and infected cells themselves are reported to be regulatory T cell-like. In this study, we investigated the regulation of HTLV-1-infected cells by immune suppressive cytokines, TGF-beta and IL-10. We found that the infected cell lines tested responded to TGF-beta weakly whereas IL-10 may promote proliferation of HTLV-1-infected cells.
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