Development of methodology for science of lifestyle habits in epidemiological research

• Project/Area Number: 16K00063
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Statistical science
• Research Institution: University of the Ryukyus
• Principal Investigator: Yonemoto Koji 琉球大学, 医学部, 教授 (90398090)
• Co-Investigator(Kenkyū-buntansha): 船木 真理 徳島大学, 病院, 特任教授 (10467821) ; 秦 明子 徳島大学, 病院, 特任助教 (20570948) ; 熊谷 秋三 九州大学, キャンパスライフ・健康支援センター, 教授 (80145193)
• Project Period (FY): 2016-04-01 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 栄養疫学 / 食事パターン / 身体活動 / 3軸加速度計 / 縮小次元回帰 / 加速度計 / 主成分分析 / 疫学 / 統計科学 / 運動疫学 / メタボリックシンドローム

Outline of Final Research Achievements

In the development of methodology for analysis of dietary habits data, the problems of existing methods of dietary pattern extraction related to disease onset were organized and new methods were developed. When the method was applied to the data of the population of Tokushima prefecture, we could extract the dietary pattern related to the onset of metabolic syndrome.
The exercise habits data revealed how physical activity habits in the Japanese are changing by analyzing the amount of physical activity measured in the same group at two points in 2009 and 2012. Furthermore, it is important to recommend not only increasing exercise but also reducing sitting time.

Academic Significance and Societal Importance of the Research Achievements

栄養データは新たに開発した方法により、既存のデータからも重要な知見を得ることが出来ることが明らかとなり、これまでのデータの価値がますます高まる。
運動習慣データは、3軸加速度計という装置を用いた客観的評価により、これまでの質問紙とは異なるリアルタイムのデータから人々の生活パターンを科学できることが示され、今後の身体活動データの在り方が明らかになった。また実際のデータ解析の結果から、身体活動の増加と座位時間の減少は必ずしも関連しておらず、ともに推奨する必要があることが分かったことは大きな社会的意義をもっていると考える。

Research Products

• [Journal Article] Longitudinal Changes of Physical Activity and Sedentary Time in the Middle-Aged and Older Japanese Population: The Hisayama Study (2019)
  • Author(s): Yonemoto Koji、Honda Takanori、Kishimoto Hiro、Yoshida Daigo、Hata Jun、Mukai Naoko、Shibata Mao、Hirakawa Yoichiro、Ninomiya Toshiharu、Kumagai Shuzo
  • Journal Title: Journal of Physical Activity and Health Volume: 16 Issue: 2 Pages: 165-171
  • DOI: 10.1123/jpah.2017-0701
  • Peer Reviewed
• [Journal Article] Objectively measured sedentary time and diabetes mellitus in a general Japanese population: the Hisayama Study (2019)
  • Author(s): Takanori Honda, Hiro Kishimoto, Naoko Mukai, Jun Hata, Daigo Yoshida, Yoichiro Hirakawa, Mao Shibata, Tomoyuki Ohara, Shuzo Kumagai, Toshiharu Ninomiya
  • Journal Title: J Diab Invest Volume: 10 Issue: 3 Pages: 809-816
  • DOI: 10.1111/jdi.12968
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Soy product and isoflavone intake associations with allergic diseases in Japanese workers: rhinitis, dermatitis and asthma (2018)
  • Author(s): Nakamoto M, Shuto E, Nakamoto A, Hata A, Aki N, Shikama Y, Bando Y, Ichihara T, Minagawa T, Tamura A, Kuwamura Y, Funaki M, Sakai T.
  • Journal Title: Asia Pac J Clin Nutr Volume: 27 Pages: 1277-1285
  • Peer Reviewed / Open Access
• [Journal Article] Patterns and levels of tri-axial accelerometer-measured sedentary behavior and physical activity in a general Japanese population: the Hisayama Study (2018)
  • Author(s): Chen, T., Kishimoto, H., Honda, T., Hata, J., Kiyohara, Y., Ninomiya, T., and Kumagai, S
  • Journal Title: Journal of Epidemiology Volume: 28 Pages: 260-265
  • Peer Reviewed
• [Journal Article] Long-Term Exercise Protects against Cellular Stresses in Aged Mice (2018)
  • Author(s): Belaya Irina、Suwa Masataka、Chen Tao、Giniatullin Rashid、Kanninen Katja M.、Atalay Mustafa、Kumagai Shuzo
  • Journal Title: Oxidative Medicine and Cellular Longevity Volume: 2018 Issue: 1 Pages: 1-10
  • DOI: 10.1155/2018/2894247
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Physical frailty is associated with longitudinal decline in global cognitive function in the non-demented elderly (2018)
  • Author(s): Chen, S., Honda, T., Narazaki, K., Chen, T., Kishimoto, H., Haeuchi, Y., and Kumagai,S
  • Journal Title: J Nutr Health Aging Volume: 22 Pages: 82-88
  • Peer Reviewed
• [Journal Article] Remodeling of myelinated fibers and internal capillaries in distal peripheral nerves following aerobic exercise in aged rats (2018)
  • Author(s): Masahiro Sakita, Shinichiro Murakami, Hidemi Fujino, Satoshi Hayashi, Kazuyoshi Kameyama, Takafumi Saito, Shuzo Kumagai
  • Journal Title: Journal of Applied Physiology Volume: 125 Issue: 4 Pages: 1051-1061
  • DOI: 10.1152/japplphysiol.00257.2018
  • Peer Reviewed
• [Journal Article] Associations between intake of dietary fermented soy food and concentrations of inflammatory markers: a cross‐sectional study in Japanese workers (2018)
  • Author(s): Yang X, Nakamoto M, Shuto E, Hata A, Aki N, Shikama Y, Bando Y, Ichihara T, Minamigawa T, Kuwamura Y, Tamura A, Uemura H, Arisawa K, Funaki M, Sakai T
  • Journal Title: The Journal of Medical Investigation Volume: 65 Issue: 1.2 Pages: 74-80
  • DOI: 10.2152/jmi.65.74
  • NAID: 130006575620
  • ISSN: 1343-1420, 1349-6867
  • Peer Reviewed / Open Access
• [Journal Article] Physical frailty is associated with longitudinal decline in global cognitive function in the non-demented elderly (2018)
  • Author(s): Chen, S., Honda, T., Narazaki, K., Chen, T., Kishimoto, H., Haeuchi, Y., and Kumagai, S
  • Journal Title: J Nutr Health Aging Volume: 22 Issue: 1 Pages: 82-88
  • DOI: 10.1007/s12603-017-0924-1
  • Peer Reviewed / Open Access
• [Journal Article] Development and validation of a risk assessment tool for gastric cancer in a general Japanese population (2018)
  • Author(s): Iida M, Ikeda F, Hata J, Hirakawa Y, Ohara T, Mukai N, Yoshida D, Yonemoto K, Esaki M.
  • Journal Title: Gastlic Cancer Volume: 21 Issue: 3 Pages: 383-390
  • DOI: 10.1007/s10120-017-0768-8
  • NAID: 40021539345
  • Peer Reviewed
• [Journal Article] Morning and Evening Blood Pressures Are Associated With Intima-Media Thickness in a General Population ― The Hisayama Study ― (2017)
  • Author(s): Sakata S, Hata J, Fukuhara, M, Yonemoto, K, Mukai N, Yoshida D, Kishimoto H, Ohtsubo T, Kitazono T, Kiyohara Y, Ninomiya T
  • Journal Title: Circulation Journal Volume: 81 Issue: 11 Pages: 1647-1653
  • DOI: 10.1253/circj.CJ-16-1306
  • NAID: 130006179861
  • ISSN: 1346-9843, 1347-4820
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Sedentary bout durations and metabolic syndrome among working adults: A prospective cohort study (2016)
  • Author(s): Honda T, Chen S, Yonemoto K, Kishimoto H, Chen T, Narazaki K, Haeuchi Y, Kumagai S.
  • Journal Title: BMC Public Health Volume: 16 Issue: 1 Pages: 888-888
  • DOI: 10.1186/s12889-016-3570-3
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Presentation] 高齢者における質問紙を用いた座位時間評価の信頼性と妥当性に関する検討 (2019)
  • Author(s): 永吉翔、矢次春風、本田貴紀、森山善彦、岸本裕歩、熊谷秋三
  • Organizer: 第20回日本健康支援学会年次学術集大会
• [Presentation] 地域在住高齢者おける身体活動および座位行動と体力・運動機能の関連：篠栗元気もん研究 (2019)
  • Author(s): 広田美江、岸本裕歩、楢崎兼司、陳 涛、熊谷秋三
  • Organizer: 第20回日本健康支援学会年次学術集大会
• [Presentation] 地域在住高齢者における客観的に測定した中高強度身体活動量の変化に対する関連因子：2年間の縦断研究 (2019)
  • Author(s): 徐艶崢、楢﨑兼司、陳 涛、熊谷秋三
  • Organizer: 第20回日本健康支援学会年次学術集大会
• [Presentation] 大学生のメンタルヘルスとその関連要因に関する追跡調査 (2019)
  • Author(s): 松下智子、高柳茂美、福盛英明、熊谷秋三
  • Organizer: 第20回日本健康支援学会年次学術集大会
• [Presentation] フレイル評価システム「フレイル予防通信簿」の開発 (2019)
  • Author(s): 星野久美子、平山耕一、楢﨑兼司、陳三妹、本田貴紀、陳涛、熊谷秋三
  • Organizer: 第20回日本健康支援学会年次学術集大会
• [Presentation] 介護予防をめざした活動量促進のためのフィードバックシートの開発と応用 (2019)
  • Author(s): 中村彩希、矢次春風、陳 斯、陳 涛、町田由紀子、岸本裕歩、熊谷秋三
  • Organizer: 第20回日本健康支援学会年次学術集大会
• [Presentation] 地域在住高齢者における対面型および遠隔型の運動指導の効果検証：糸島フレイル研究 (2019)
  • Author(s): 町田由紀子、陳 涛、中村彩希、熊谷秋三、矢次春風、陳 斯、岸本裕歩、山津幸司、南伸太郎、小池城司
  • Organizer: 第20回日本健康支援学会年次学術集大会
• [Presentation] Cross-cultural adaptation and validation of the FRAIL scale and its modified version in a Japanese community- dwelling older adults: Itoshima Frail Study (2019)
  • Author(s): Chen, S., Kishimoto H., Susaki Y., Chen T., Kumagai S
  • Organizer: 第20回日本健康支援学会年次学術集大会
• [Presentation] 地域在住高齢者におけるCross testと運動機能との関連：糸島フレイル研究 (2019)
  • Author(s): 藤谷順三、岸本裕歩、陳 涛、熊谷秋三
  • Organizer: 第20回日本健康支援学会年次学術集大会
• [Presentation] 地域在住高齢者の客観的データに基づく身体活動・座位行動の標準値に関するコホート統合研究 (2019)
  • Author(s): 矢次春風、野藤 悠、岸本裕歩、陳 涛、熊谷秋三
  • Organizer: 第20回日本健康支援学会年次学術集大会
• [Presentation] 労働中の座位行動の身体活動への置き換えによる肥満および心血管系リスク指標の変化 (2019)
  • Author(s): 諏訪雅貴、井本貴之、木田 明、小澤謙二、岩瀬三紀、横地 隆、岸本裕歩、熊谷秋三
  • Organizer: 第20回日本健康支援学会年次学術集大会
• [Presentation] IoTを用いた運動行動変容のためのプログラム開発：フレイルの観点から (2019)
  • Author(s): 熊谷秋三
  • Organizer: 平成30年度AMEDICT関連事業研究成果報告会
• [Presentation] 徳島県における血中アディポネクチンとPrediabetes発症との関連 (2018)
  • Author(s): 秦明子、安藝菜奈子、三好雅士、中尾隆之、市原多香子、田村綾子、南川貴子、桑村 由美、船木真理
  • Organizer: 第61回日本糖尿病学会年次学術集会
• [Presentation] Serum Total Adiponectin Level is Associated with Incident Prediabetes in Japanese Workers (2018)
  • Author(s): Akiko Hata, Masashi Miyoshi, Takayuki Nakao, Takako Ichihara, Ayako Tamura, Takako Minagawa, Yumi Kuwamura, Makoto Funaki
  • Organizer: 第78回米国糖尿病学会年次学術集会
  • Int'l Joint Research
• [Presentation] Serum total adiponectin level and new onset of prediabetes in Japanese workers: Tokushima Cohort Study (2018)
  • Author(s): Akiko Hata, Masashi Miyoshi, Takayuki Nakao, Takako Ichihara, Ayako Tamura, Takako Minagawa, Yumi Kuwamura, Makoto Funaki
  • Organizer: 12th IDF-WPR Congress 2018 & 10th AASD Scientific Meeting (IDF-WPR 2018).
  • Int'l Joint Research
• [Presentation] for Cohort Studies of Memory in an International Consortium (COSMIC): Relationship between Apolipoprotein-ε4 and cognitive decline and the moderating effects of age, sex, and ethnicity (2018)
  • Author(s): Makkar, S R., Lipnicki, D M., Crawford, JD., Thalamuthu, A., Kochan, NA., Brodaty, H., Sachdev, PS
  • Organizer: The COSMIC collaboration. Alzheimer’s Association International Conference,
  • Int'l Joint Research
• [Presentation] for Cohort Studies of Memory in an International Consortium (COSMIC): Age-dependent association between body mass index (BMI) and cognitive decline in diverse ethno-regional groups (2018)
  • Author(s): Makkar, S R., Lipnicki, D M., Crawford, JD., Thalamuthu, A., Kochan, NA., Brodaty, H., Sachdev, PS
  • Organizer: The COSMIC collaboration. Alzheimer’s Association International Conference
  • Int'l Joint Research
• [Presentation] for Cohort Studies of Memory in an International Consortium (COSMIC): Determinants of cognitive performance and decline in diverse ethno-regional groups (2018)
  • Author(s): Lipnicki, DM., Makkar, SR., Crawford, JD., Thalamuthu, A., Kochan, A., Brodaty, H., Sachdev, PS
  • Organizer: the COSMIC collaboration. Alzheimer’s Association International Conference
  • Int'l Joint Research
• [Presentation] 痛みの数と手段的日常生活動作および心理的因子との関連性 (2018)
  • Author(s): 齊藤貴文，崎田正博，熊谷秋三
  • Organizer: 第23回日本ペインリハビリテーション学会学術大会
• [Presentation] 痛みの数と手段的日常生活動作，運動機能および身体活動量との関連性 (2018)
  • Author(s): 齊藤貴文，崎田正博，熊谷秋三
  • Organizer: 第6回日本運動器理学療法学会学術大会
• [Presentation] 身体活動疫学研究によるエビデンスに基づく認知症の発症予防. 委員会・指定シンポジウム:認知症の新規発症を減らすためにできることは何か？ (2018)
  • Author(s): 熊谷秋三（シンポジスト）
  • Organizer: 第114回日本精神神経学会学術総会
• [Presentation] Epidemiology of physical frailty in community-dwelling elderly (2018)
  • Author(s): Shuzo Kumagai (Keynote Speaker):
  • Organizer: 2018 Xiangya Nursing International Forum (4th)--Elderly Care: Innovation, Education & Development
  • Int'l Joint Research
• [Presentation] 客観的評価に基づく身体活動・座位行動の疫学: 証拠に基づく健康支援の展開 (2018)
  • Author(s): 熊谷秋三
  • Organizer: 平成30年度琉球大学先端医学研究センター第2回生物統計・疫学公開講演会
  • Invited
• [Presentation] 身体活動・座位行動の疫学～生活習慣病・介護予防の観点から (2018)
  • Author(s): 熊谷秋三
  • Organizer: 第91回徳島大学糖尿病臨床・研究開発センター 講演会
  • Invited
• [Presentation] メタボにつながる食習慣：糖尿病死亡率ワースト1位の徳島県での研究結果〜 (2018)
  • Author(s): 米本孝二、秦明子
  • Organizer: 平成30年度琉球大学先端医学研究センター第3回生物統計・疫学公開講演会
  • Invited
• [Presentation] 生活習慣病・介護予防の身体活動疫学研究 (2018)
  • Author(s): 熊谷秋三
  • Organizer: 琉球大学「生物統計・疫学公開講演会」
  • Invited
• [Presentation] Physical frailty phenotype and risk of functional disability in community-dwelling older adults: a prospective study (2018)
  • Author(s): Sanmei Chen, Kenji Narazaki, Yuka Haeuchi, Takanori Honda, Tao Chen, Hiro Kishimoto , Shuzo Kumagai
  • Organizer: 第19回日本健康支援学会年次学術集大会
• [Presentation] 男性勤労者の全身持久力と身体活動量の組み合わせと内臓脂肪型肥満との関連～TMCPAF スタディ＊～ ＊Toyota Motor Corporation Physical Activity and Fitness Study (2018)
  • Author(s): 八木香里, 陳 涛, 陳 三妹, 諏訪雅貴, 井本貴之, 木田 明, 小澤謙二. 岩瀬三紀, 横地 隆, 岸本裕歩, 熊谷秋三
  • Organizer: 第19回日本健康支援学会年次学術集大会
• [Presentation] Associations of objectively-measured physical activity, sedentary behavior and cardiorespiratory fitness with metabolic syndrome in Japanese male workers: TMCPF study (2017)
  • Author(s): Kaori Yagi, Tao Chen, Sanmei Chen, Masataka Suwa, Takayuki Imoto, Akira Kida, Mitsunori Iwase, Takashi Yokochi, Shuzo Kumagai
  • Organizer: 24th European Congress on Obesity
  • Int'l Joint Research
• [Presentation] 勤労者におけるSedentary boutの関連因子に関する研究 (2017)
  • Author(s): 池永千寿子,八木香里, 陳三妹,本田貴紀,熊谷秋三
  • Organizer: 第20回日本運動疫学会学術総会
• [Presentation] 地域在住高齢女性のプレフレイル罹患率と関連要因の検討 (2017)
  • Author(s): 内藤紘一、村田伸、堀江淳、白岩加代子、安彦鉄平、岩瀨弘明、熊谷秋三
  • Organizer: 第20回日本運動疫学会学術総会
• [Presentation] Objective Physical Activity, Sedentary Time and Incident Disability in Older Adults (2017)
  • Author(s): Tao Chen, Yuka Haeuchi, Takanori Honda, Sanmei Chen, Kenji Narazaki, Sho Nagayoshi, Shuzo Kumagai
  • Organizer: The 21 IAGGWorld Congress of Gerontology and Geriatrics
  • Int'l Joint Research
• [Presentation] 地域在住非糖尿病者における座位時間とインスリン抵抗性の関連：久山町研究 (2017)
  • Author(s): 本田貴紀、岸本裕歩、向井直子、秦 淳、吉田大悟、平川洋一郎、柴田舞欧、小原知之、熊谷秋三、二宮利治
  • Organizer: 第24回日本未病システム学会学術集会
• [Presentation] Association between objectively-measured sedentary behaviour patterns and cognitive function in non-demented older adults: a cross-sectional study (2016)
  • Author(s): Chen,S., Honda, T., Chen, T., Narazaki, K., Haeuchi, Y., and Kumagai, S
  • Organizer: The International Congress on Physical Activity and Public Health
  • Place of Presentation: Bangkok Thailand
  • Year and Date: 2016-11-16
  • Int'l Joint Research
• [Presentation] Factors associated with accelerometer adherence in community-dwelling older adults (2016)
  • Author(s): Zheng, W., Chen, T., Chen, S., Haeuch, Y., and Kumagai, S
  • Organizer: The International Congress on Physical Activity and Public Health
  • Place of Presentation: Bangkok Thailand
  • Year and Date: 2016-11-16
  • Int'l Joint Research
• [Presentation] Associations of objectively measured sedentary time with metabolic syndrome in a general Japanese population: the Hisayama Study (2016)
  • Author(s): Honda, T., Kishimoto, H., Mukai,N., Hata, J., Yoshida, D., Ohara, T., Kumagai, S., Kiyohara, Y., Ninomiya, T.
  • Organizer: The International Congress on Physical Activity and Public Health
  • Place of Presentation: Bangkok Thailand
  • Year and Date: 2016-11-16
  • Int'l Joint Research
• [Presentation] Associated factors of objectively-measured sedentary time among Japanese workers: a cross-sectional analysis. (2016)
  • Author(s): Ikenaga, C., Chen, S., and Kumagai,S
  • Organizer: The International Congress on Physical Activity and Public Health
  • Place of Presentation: Bangkok Thailand
  • Year and Date: 2016-11-16
  • Int'l Joint Research
• [Presentation] 地域住民における座位時間と糖尿病の関連：久山町研究 (2016)
  • Author(s): 本田貴紀,岸本裕歩,向井直子,秦 淳,吉田大悟,平川洋一郎,柴田舞欧,小原知之,熊谷秋三,清原 裕,二宮利治
  • Organizer: 第23回日本未病システム学会学術集会
  • Place of Presentation: 九州大学医学部百年講堂（福岡県福岡市）
  • Year and Date: 2016-11-05
• [Presentation] Internet-based behavior therapy for lifestyle changes in Japanese patients with diabetes: Results of a feasibility study (2016)
  • Author(s): Yamatsu, K., Tajiri, Y., and Kumagai, S
  • Organizer: 34th World Congress of Sports Medicine
  • Place of Presentation: Ijubjana, Slovenia
  • Year and Date: 2016-09-29
  • Int'l Joint Research
• [Presentation] Combination risk to sleep disturbance of physical activity and sedentary behavior by difference between community-dwelling elderly Japanese people with and without musculoskeletal pain (2016)
  • Author(s): Saito, T., Sakita, M., and Kumagai, S
  • Organizer: 16th World Congress on Pain 2016
  • Place of Presentation: 横浜市
  • Year and Date: 2016-09-26
  • Int'l Joint Research
• [Presentation] 男性勤労者の客観的に評価された身体活動・座位行動と内臓脂肪面積との関連：TMCPAFスタディ (2016)
  • Author(s): 八木香里、陳 涛、陳 三妹、諏訪雅貴、井本貴之、木田 明、岩瀬三紀、横地隆、熊谷秋三
  • Organizer: 第71回日本体力医学会大会
  • Place of Presentation: いわて県民情報交流センター（岩手県盛岡市）
  • Year and Date: 2016-09-23
• [Presentation] Identifying a Dietary Pattern Associated with Metabolic Syndrome by Reduced Rank Regression in Japanese Male Workers (2016)
  • Author(s): Akiko Hata, Koji Yonemoto, Nanako Aki, Tohru Sakai, Emi Shuto, Takayuki Nakao, Masashi Miyoshi, Makoto Funaki
  • Organizer: American Diabetes Association's 76th Scientific Sessions
  • Place of Presentation: 米国ニューオーリンズ
  • Year and Date: 2016-06-10
  • Int'l Joint Research
• [Presentation] 徳島県におけるメタボリックシンドロームと関連する食事パターンの検討 (2016)
  • Author(s): 秦 明子, 米本 孝二, 安藝 菜奈子, 酒井 徹, 首藤 恵泉, 中尾 隆之, 三好 雅士, 船木 真理
  • Organizer: 第59回日本糖尿病学会年次学術集会
  • Place of Presentation: みやこめっせ （京都府京都市）
  • Year and Date: 2016-05-19